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Start Over Author "Sergio Mancini" Journal gynecologic oncology
3 results on '"Sergio Mancini"'

1. Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data

Author

Aggarwal, Simi, Bronger, Holger, Brown, Elizabeth B., Buck, Martin, Bukhari, Syed A., Coghlan, Edwina, Cope, Nichola, de Almeida, Michelle Samora, De Kroon, Cornelius D., Dean, Andrew, Devlin, Michael-John, Ditzel, Helena M., Drecoll, Enken, Ebata, Takahiro, Fagotti, Anna, Faruqi, Asma, Feeney, Laura, Gupta, Kavita, Harley, Ian, Inzani, Frediano, Jeyarajah, Arjun R., Koay, M.H. Eleanor, Kroep, Judith R., Lee, Jung-Yun, Leung, Yee, Lockley, Michelle, Loft, Alice R., MaGee, Daniel, Manchanda, Ranjit, McKenna, Sarah, Midha, Divya, Millan, David, Millar, Joanne, Miller, Rowan, Mohan, Ganendra R., Mughal, Sohail, Mukhopadhyay, Asima, Nicolau, Sergio Mancini, Nevin, James, Oakley, Abigail S., Quigley, Mary, Rai, Bhavana, Rajwanshi, Arvind, Salfinger, Stuart G., Scambia, Giovanni, Scatchard, Kate, Schmalfeldt, Barbara, Simcock, Bryony, Singh, Priya, Strickland, Kyle C., Suri, Vainta, Syed, Sheeba, Sykes, Peter, Tamura, Kenji, Tan, Adeline, Tan, Jason, Thompson, Emily, Tinker, Anna V., Trevisan, Georgia, Uyeda, Maria Gabriela Baumgarten Kuster, Vaughan, Michelle M., Weichert, Wilko, Williams, Anthony, Williams, Sarah, Yoshida, Hiroshi, Zorzato, Pier Carlo, Cohen, Paul A., Powell, Aime, Böhm, Steffen, Gilks, C. Blake, Stewart, Colin J.R., Meniawy, Tarek M., Bulsara, Max, Avril, Stefanie, Brockbank, Eleanor C., Bosse, Tjalling, de Azevedo Focchi, Gustavo Rubino, Ganesan, Raji, Glasspool, Rosalind M., Howitt, Brooke E., Kim, Hyun-Soo, Le, Nhu D., Mandalia, Trupti, McCluggage, W. Glenn, McNeish, Iain, Srinivasan, Radhika, Tan, Yun Yi, van der Griend, Rachael, Yunokawa, Mayu, Zannoni, Gian F., and Singh, Naveena

Published
2019
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2. Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data

Author

Cohen, Paul A., primary, Powell, Aime, additional, Böhm, Steffen, additional, Gilks, C. Blake, additional, Stewart, Colin J.R., additional, Meniawy, Tarek M., additional, Bulsara, Max, additional, Avril, Stefanie, additional, Brockbank, Eleanor C., additional, Bosse, Tjalling, additional, de Azevedo Focchi, Gustavo Rubino, additional, Ganesan, Raji, additional, Glasspool, Rosalind M., additional, Howitt, Brooke E., additional, Kim, Hyun-Soo, additional, Lee, Jung-Yun, additional, Le, Nhu D., additional, Lockley, Michelle, additional, Manchanda, Ranjit, additional, Mandalia, Trupti, additional, McCluggage, W. Glenn, additional, McNeish, Iain, additional, Midha, Divya, additional, Srinivasan, Radhika, additional, Tan, Yun Yi, additional, van der Griend, Rachael, additional, Yunokawa, Mayu, additional, Zannoni, Gian F., additional, Singh, Naveena, additional, Aggarwal, Simi, additional, Bronger, Holger, additional, Brown, Elizabeth B., additional, Buck, Martin, additional, Bukhari, Syed A., additional, Coghlan, Edwina, additional, Cope, Nichola, additional, de Almeida, Michelle Samora, additional, De Kroon, Cornelius D., additional, Dean, Andrew, additional, Devlin, Michael-John, additional, Ditzel, Helena M., additional, Drecoll, Enken, additional, Ebata, Takahiro, additional, Fagotti, Anna, additional, Faruqi, Asma, additional, Feeney, Laura, additional, Gupta, Kavita, additional, Harley, Ian, additional, Inzani, Frediano, additional, Jeyarajah, Arjun R., additional, Koay, M.H. Eleanor, additional, Kroep, Judith R., additional, Leung, Yee, additional, Loft, Alice R., additional, MaGee, Daniel, additional, McKenna, Sarah, additional, Millan, David, additional, Millar, Joanne, additional, Miller, Rowan, additional, Mohan, Ganendra R., additional, Mughal, Sohail, additional, Mukhopadhyay, Asima, additional, Nicolau, Sergio Mancini, additional, Nevin, James, additional, Oakley, Abigail S., additional, Quigley, Mary, additional, Rai, Bhavana, additional, Rajwanshi, Arvind, additional, Salfinger, Stuart G., additional, Scambia, Giovanni, additional, Scatchard, Kate, additional, Schmalfeldt, Barbara, additional, Simcock, Bryony, additional, Singh, Priya, additional, Strickland, Kyle C., additional, Suri, Vainta, additional, Syed, Sheeba, additional, Sykes, Peter, additional, Tamura, Kenji, additional, Tan, Adeline, additional, Tan, Jason, additional, Thompson, Emily, additional, Tinker, Anna V., additional, Trevisan, Georgia, additional, Uyeda, Maria Gabriela Baumgarten Kuster, additional, Vaughan, Michelle M., additional, Weichert, Wilko, additional, Williams, Anthony, additional, Williams, Sarah, additional, Yoshida, Hiroshi, additional, and Zorzato, Pier Carlo, additional

Published
2019
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3. Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT): A review of 47 cases

Author

David M. Gershenson, Elizabeth D. Euscher, Donato Callegaro-Filho, Kathleen M. Schmeler, Pedro T. Ramirez, Patricia J. Eifel, Mark F. Munsell, Sergio Mancini Nicolau, Alpa M. Nick, and Renato Moretti Marques

Subjects
Adult, 0301 basic medicine, Oncology, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Small-cell carcinoma, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Adjuvant therapy, Humans, Carcinoma, Small Cell, Stage (cooking), Child, Retrospective Studies, Ovarian Neoplasms, Chemotherapy, business.industry, Obstetrics and Gynecology, Cancer, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Radiation therapy, 030104 developmental biology, Child, Preschool, 030220 oncology & carcinogenesis, Hypercalcemia, Female, business, Rare disease
Abstract

Objective Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) is a rare disease with a poor prognosis. SCCOHT has recently been shown to be associated with SMARCA4 gene mutations as well as molecular and genetic similarities to malignant rhabdoid tumors (MRT). The objective of our study is to describe the clinical characteristics, treatment modalities and outcomes of 47 patients with SCCOHT. Methods We performed a retrospective analysis of 47 patients with SCCOHT evaluated at MD Anderson Cancer Center between 1990 and 2014. Medical records were reviewed for demographic information, pathologic findings, treatment regimens and outcomes. Results Median age at diagnosis was 30years (range 5–46). All patients underwent surgery with unilateral salpingo-oophorectomy (USO) performed in 26 patients (55%), and hysterectomy with bilateral salpingooophorectomy (BSO) in 21 patients (45%). Sixteen patients (34.0%) had stage I disease, six (12.8%) stage II, 23 (48.9%) stage III, and two patients (4.3%) had stage IV disease. Information on adjuvant treatment was available for 43 patients: 83.3% received chemotherapy alone, 9.5% chemotherapy followed by radiotherapy, 2.4% chemoradiation, and 4.8% did not receive any adjuvant therapy. Median follow-up was 13.2months (range, 0.1 to 210.7) with a median overall survival of 14.9months. Multi-agent chemotherapy and radiotherapy were associated with a better prognosis. Conclusion Our findings suggest that aggressive therapy including multi-agent chemotherapy and possibly radiotherapy may extend survival. Further study is needed to improve outcomes in these patients including the adoption of systemic therapies used in MRT as well as the development of novel agents targeting specific mutations.

Published
2016
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