1. Fertility outcome after treatment of retained products of conception: a systematic review
- Author
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Tjalina Hamerlynck, Jan Bosteels, Hannelore Van der Veken, Steven Weyers, Dora Meyers, Meyers, Dora, Van der Veken, Hannelore, and Bosteels, Jan
- Subjects
medicine.medical_specialty ,RESECTION ,medicine.medical_treatment ,Reproductive medicine ,MEDLINE ,lcsh:Surgery ,OPERATIVE ,Cochrane Library ,PLACENTAL REMNANTS ,DIAGNOSIS ,lcsh:Gynecology and obstetrics ,RESIDUAL TROPHOBLASTIC TISSUE ,law.invention ,03 medical and health sciences ,REMOVAL ,0302 clinical medicine ,Randomized controlled trial ,law ,CURETTAGE ,Reproductive ,Medicine and Health Sciences ,medicine ,lcsh:RG1-991 ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Obstetrics ,Retained products of conception ,Obstetrics and Gynecology ,lcsh:RD1-811 ,Curettage ,Reproductive outcome ,Clinical trial ,Treatment ,Fertility ,Hysteroscopy ,MORCELLATION ,030220 oncology & carcinogenesis ,Relative risk ,outcome ,Systematic review ,Surgery ,business ,HYSTEROSCOPIC MANAGEMENT ,HYSTEROSCOPY - Abstract
Background Treatment of retained products of conception (RPOC) can be expectant, medical or operative. Surgical removal of RPOC may lead to intrauterine adhesions (IUA) and Asherman’s syndrome. Objective To evaluate how treatment options for RPOC affect future fertility by means of a systematic review. Search strategy MEDLINE, EMBASE, The Cochrane Library, and clinical trial registers were searched, and reference lists were scanned. Selection criteria Randomised controlled trials (RCT) comparing different treatment options for RPOC (conservative, medical or surgical treatment, including curettage and/or hysteroscopic techniques, with or without application of anti-adhesion therapy), in women of reproductive age, were eligible for inclusion. Data collection and analysis Reviewers independently performed data extraction and quality of evidence assessment. For dichotomous variables, results were presented as risk ratio (RR) with 95% CI. Main results Two studies were included. Nonsignificant differences were observed between the use of an anti-adhesion barrier gel versus no treatment after operative hysteroscopy in IUAs (RR 0.32, 95% CI 0.04 to 2.80, P value = 0.30) and clinical pregnancy (RR 2.22, 95% CI 0.67 to 7.42, P value = 0.19), and between hysteroscopic morcellation versus loop resection in IUAs (RR 0.86, 95% CI 0.06 to 13.12, P value = 0.91). Conclusion There is insufficient evidence on how different treatment options for RPOC affect future reproductive outcomes. Results from ongoing RCTs are needed to guide clinicians towards choosing the best treatment.
- Published
- 2018