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1. Accuracy of leukocyte alkaline phosphatase score to predict JAK2 V617F mutation.

Author

Basquiera AL, Fassetta F, Soria N, Barral JM, Ricchi B, and García JJ

Subjects
Adult, Aged, Amino Acid Substitution, Area Under Curve, Female, Humans, Male, Middle Aged, Myeloproliferative Disorders enzymology, Neutrophil Activation, Predictive Value of Tests, Single-Blind Method, Alkaline Phosphatase blood, Janus Kinase 2 genetics, Leukocytes enzymology, Mutation, Missense, Myeloproliferative Disorders blood, Point Mutation
Abstract

Granulocyte activation parameters have been described in patients with myeloproliferative disorders (MPD). We have evaluated the accuracy of leukocyte alkaline phosphatase (LAP) score to predict JAK2 V617F mutation. LAP score was obtained using a cytochemical reaction in granulocytes of patients' peripheral blood with MPD.

Published
2007
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