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Your search keyword '"Pelzl, Lisann"' showing total 5 results
Start Over Author "Pelzl, Lisann" Journal haematologica
5 results on '"Pelzl, Lisann"'

3. Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia

Author

Althaus, Karina, primary, Möller, Peter, additional, Uzun, Günalp, additional, Singh, Anurag, additional, Beck, Annika, additional, Bettag, Martin, additional, Bösmüller, Hans, additional, Guthoff, Martina, additional, Dorn, Franziska, additional, Petzold, Gabor C., additional, Henkes, Hans, additional, Heyne, Nils, additional, Jumaa, Hassan, additional, Kreiser, Kornelia, additional, Limpach, Caroline, additional, Luz, Beate, additional, Maschke, Matthias, additional, Müller, Janis A., additional, Münch, Jan, additional, Nagel, Simon, additional, Pötzsch, Bernd, additional, Müller, Jens, additional, Schlegel, Christoph, additional, Viardot, Andreas, additional, Bäzner, Hansjörg, additional, Wolf, Marc, additional, Pelzl, Lisann, additional, Warm, Verena, additional, Willinek, Winfried A., additional, Steiner, Jochen, additional, Schneiderhan-Marra, Nicole, additional, Vollherbst, Dominik, additional, Sachs, Ulrich J., additional, Fend, Falko, additional, and Bakchoul, Tamam, additional

Published
2021
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5. Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan.

Author

Marini I, Zlamal J, Faul C, Holzer U, Hammer S, Pelzl L, Bethge W, Althaus K, and Bakchoul T

Subjects
Animals, Cohort Studies, Humans, Megakaryocytes, Autoantibodies, Blood Platelets, Thrombopoiesis
Abstract

Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet life span in immune thrombocytopenia. Herein, we report on novel effector functions of autoantibodies from immune thrombocytopenic patients which might interfere with the clinical picture of the disease. Data from our study show that a subgroup of autoantibodies is able to induce cleave of sialic acid residues from the surface of human platelets and megakaryocytes. Moreover, autoantibody-mediated desialylation interferes with the interaction between cells and extracellular matrix proteins leading to impaired platelet adhesion and megakaryocyte differentiation. Using a combination of ex vivo model of thrombopoiesis, a humanized animal model, and a clinical cohort study, we demonstrate that cleavage of sialic acid induces significant impairment in production, survival as well as function of human platelets. These data may indicate that prevention of desialylation should be investigated in the future in clinical studies as a potential therapeutic approach to treat bleeding in immune thrombocytopenia.

Published
2021
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