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Start Over Author "Raul Rabadan" Journal haematologica
6 results on '"Raul Rabadan"'

1. Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses

Author

Luciano Cascione, Andrea Rinaldi, Alessio Bruscaggin, Chiara Tarantelli, Alberto J. Arribas, Ivo Kwee, Lorenza Pecciarini, Afua A. Mensah, Valeria Spina, Elaine Y.L. Chung, Lodovico Terzi di Bergamo, Stephan Dirnhofer, Alexandar Tzankov, Roberto N. Miranda, Ken H. Young, Alexandra Traverse-Glehen, Gianluca Gaidano, Steven H. Swerdlow, Randy Gascoyne, Raul Rabadan, Maurilio Ponzoni, Govind Bhagat, Davide Rossi, Emanuele Zucca, and Francesco Bertoni

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2019
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2. Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target

Author

Maria Rosaria Sapienza, Francesco Abate, Federica Melle, Stefania Orecchioni, Fabio Fuligni, Maryam Etebari, Valentina Tabanelli, Maria Antonella Laginestra, Alessandro Pileri, Giovanna Motta, Maura Rossi, Claudio Agostinelli, Elena Sabattini, Nicola Pimpinelli, Mauro Truni, Brunangelo Falini, Lorenzo Cerroni, Giovanna Talarico, Rossana Piccioni, Stefano Amente, Valentina Indio, Giuseppe Tarantino, Francesco Brundu, Marco Paulli, Emilio Berti, Fabio Facchetti, Gaetano Ivan Dellino, Francesco Bertolini, Claudio Tripodo, Raul Rabadan, and Stefano A. Pileri

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective therapy. In order to identify genetic alterations useful for a new treatment design, we used whole-exome sequencing to analyze 14 BPDCN patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program to be the most significantly undermined (P

Published
2019
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3. Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia

Author

Silvia Rasi, Hossein Khiabanian, Carmela Ciardullo, Lodovico Terzi-di-Bergamo, Sara Monti, Valeria Spina, Alessio Bruscaggin, Michaela Cerri, Clara Deambrogi, Lavinia Martuscelli, Alessandra Biasi, Elisa Spaccarotella, Lorenzo De Paoli, Valter Gattei, Robin Foà, Raul Rabadan, Gianluca Gaidano, and Davide Rossi

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2016
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4. Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses

Author

Chiara Tarantelli, Alexandar Tzankov, Ivo Kwee, Afua Adjeiwaa Mensah, Roberto N. Miranda, Valeria Spina, Lorenza Pecciarini, Gianluca Gaidano, Alberto J. Arribas, Maurilio Ponzoni, Alexandra Traverse-Glehen, Stephan Dirnhofer, Govind Bhagat, Alessio Bruscaggin, Elaine Y.L. Chung, Randy D. Gascoyne, Lodovico Terzi di Bergamo, Francesco Bertoni, Steven H. Swerdlow, Raul Rabadan, Ken H. Young, Davide Rossi, Andrea Rinaldi, Emanuele Zucca, and Luciano Cascione

Subjects
Regulation of gene expression, Genetics, Extramural, High-Throughput Nucleotide Sequencing, MALT lymphoma, Lymphoma, B-Cell, Marginal Zone, Hematology, Biology, Prognosis, medicine.disease, DNA sequencing, Epigenesis, Genetic, Lymphoma, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Biomarkers, Tumor, medicine, Humans, Epigenetics, Online Only Articles, B cell, Epigenesis
Published
2019

5. Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target

Author

Fabio Facchetti, Emilio Berti, Claudio Tripodo, Maryam Etebari, Giovanna Motta, Nicola Pimpinelli, Fabio Fuligni, Stefano Pileri, Gaetano Ivan Dellino, Alessandro Pileri, Claudio Agostinelli, Valentina Indio, Marco Paulli, Stefania Orecchioni, Stefano Amente, Federica Melle, Giovanna Talarico, Maria Antonella Laginestra, Giuseppe Tarantino, Francesco Bertolini, Maura Rossi, Elena Sabattini, Francesco Abate, Raul Rabadan, Valentina Tabanelli, Lorenzo Cerroni, Francesco Gavino Brundu, Mauro Truni, Rossana Piccioni, Maria Rosaria Sapienza, Brunangelo Falini, Sapienza M.R., Abate F., Melle F., Orecchioni S., Fuligni F., Etebari M., Tabanelli V., Laginestra M.A., Pileri A., Motta G., Rossi M., Agostinelli C., Sabattini E., Pimpinelli N., Truni M., Falini B., Cerroni L., Talarico G., Piccioni R., Amente S., Indio V., Tarantino G., Brundu F., Paulli M., Berti E., Facchetti F., Dellino G.I., Bertolini F., Tripodo C., Rabadan R., Pileri S.A., Sapienza, M. R., Abate, F., Melle, F., Orecchioni, S., Fuligni, F., Etebari, M., Tabanelli, V., Laginestra, M. A., Pileri, A., Motta, G., Rossi, M., Agostinelli, C., Sabattini, E., Pimpinelli, N., Truni, M., Falini, B., Cerroni, L., Talarico, G., Piccioni, R., Amente, S., Indio, V., Tarantino, G., Brundu, F., Paulli, M., Berti, E., Facchetti, F., Dellino, G. I., Bertolini, F., Tripodo, C., Rabadan, R., Pileri, S. A., Sapienza, Maria Rosaria, Abate, Francesco, Melle, Federica, Orecchioni, Stefania, Fuligni, Fabio, Etebari, Maryam, Tabanelli, Valentina, Laginestra, Maria Antonella, Pileri, Alessandro, Motta, Giovanna, Rossi, Maura, Agostinelli, Claudio, Sabattini, Elena, Pimpinelli, Nicola, Truni, Mauro, Falini, Brunangelo, Cerroni, Lorenzo, Talarico, Giovanna, Piccioni, Rossana, Amente, Stefano, Indio, Valentina, Tarantino, Giuseppe, Brundu, Francesco, Paulli, Marco, Berti, Emilio, Facchetti, Fabio, Dellino, Gaetano Ivan, Bertolini, Francesco, Tripodo, Claudio, Rabadan, Raul, and Pileri, Stefano A

Subjects
Acute Myeloid Leukemia, Blastic plasmacytoid dendritic cell neoplasm, epigenetic mutations, Skin Neoplasms, Azacitidine, Decitabine, Plasmacytoid dendritic cell, Gene mutation, Biology, BPDCN, Article, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Histone methylation, 5’-Azacytidine, WES, medicine, Humans, Epigenetics, Exome sequencing, Regulation of gene expression, Myeloproliferative Disorders, Dendritic Cells, Genomics, Hematology, 5 -Azacytidine, Myeloid Neoplasms, Cancer research, 030215 immunology, medicine.drug
Abstract

Blastic Plasmacytoid Dendritic Cell Neoplasm is a rare and aggressive hematological malignancy currently lacking an effective therapy. To possibly identify genetic alterations useful for a new treatment design, we analyzed by whole-exome sequencing fourteen Blastic Plasmacytoid Dendritic Cell Neoplasm patients and the patient-derived CAL-1 cell line. The functional enrichment analysis of mutational data reported the epigenetic regulatory program as the most significantly undermined (P

Published
2018

6. Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia

Author

Carmela Ciardullo, Sara Monti, Gianluca Gaidano, Valter Gattei, Valeria Spina, Lavinia Martuscelli, Silvia Rasi, Robin Foà, Lorenzo De Paoli, Lodovico Terzi-di-Bergamo, Elisa Spaccarotella, Raul Rabadan, Michaela Cerri, Davide Rossi, Hossein Khiabanian, Alessandra Biasi, Clara Deambrogi, and Alessio Bruscaggin

Subjects
0301 basic medicine, Chronic lymphocytic leukemia, Ubiquitin-Protein Ligases, Gene Expression, Antineoplastic Agents, Biology, medicine.disease_cause, Inhibitor of Apoptosis Proteins, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Prospective Studies, Allele, Receptor, Notch1, Online Only Articles, neoplasms, Allele frequency, Survival analysis, Alleles, Mutation, B-Lymphocytes, Extramural, High-Throughput Nucleotide Sequencing, Hematology, medicine.disease, Phosphoproteins, Virology, Leukemia, Lymphocytic, Chronic, B-Cell, Survival Analysis, Baculoviral IAP Repeat-Containing 3 Protein, Clone Cells, Leukemia, 030104 developmental biology, 030220 oncology & carcinogenesis, RNA Splicing Factors
Abstract

Large-scale sequencing approaches have shown that chronic lymphocytic leukemia (CLL) is composed of a mosaic of leukemic subpopulations, each defined by distinct genetic lesions.[1][1]–[4][2] The application of ultra-deep-next generation sequencing (NGS) to track TP53 mutated subclones in CLL has

Published
2016

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