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Your search keyword '"Araki, Koji"' showing total 13 results
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13 results on '"Araki, Koji"'

1. Indications for sentinel lymph node biopsy in node‐negative oral cancers

Author

Ozawa, Taijiro, primary, Oze, Isao, additional, Matsuzuka, Takashi, additional, Sasaki, Eiichi, additional, Yokoyama, Junkichi, additional, Sano, Yoshie, additional, Tomifuji, Masayuki, additional, Araki, Koji, additional, Kogashiwa, Yasunao, additional, Tateya, Ichiro, additional, Agena, Shinya, additional, Sakashita, Tomohiro, additional, Tsuzuki, Hidenori, additional, Terada, Hoshino, additional, Suzuki, Hidenori, additional, Nishikawa, Daisuke, additional, Beppu, Shintarou, additional, Matoba, Takuma, additional, Mukoyama, Nobuaki, additional, Oguri, Keisuke, additional, and Hasegawa, Yasuhisa, additional

Published
2023
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5. Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real‐time indocyanine green fluorescence‐navigated sentinel node navigation surgery

Author

Araki, Koji, primary, Tomifuji, Masayuki, additional, Shiotani, Akihiro, additional, Hirano, Shigeru, additional, Yokoyama, Junkichi, additional, Tsukahara, Kiyoaki, additional, Homma, Akihiro, additional, Yoshimoto, Seichi, additional, and Hasegawa, Yasuhisa, additional

Published
2019
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7. Oncolytic Sendai virus‐induced tumor‐specific immunoresponses suppress “simulated metastasis” of squamous cell carcinoma in an immunocompetent mouse model

Author

Tanaka, Yuya, primary, Araki, Koji, additional, Tanaka, Shingo, additional, Miyagawa, Yoshihiro, additional, Suzuki, Hiroshi, additional, Kamide, Daisuke, additional, Tomifuji, Masayuki, additional, Uno, Kosuke, additional, Harada, Eiko, additional, Yamashita, Taku, additional, Ueda, Yasuji, additional, Inoue, Makoto, additional, and Shiotani, Akihiro, additional

Published
2019
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8. Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real‐time indocyanine green fluorescence‐navigated sentinel node navigation surgery.

Author

Araki, Koji, Tomifuji, Masayuki, Shiotani, Akihiro, Hirano, Shigeru, Yokoyama, Junkichi, Tsukahara, Kiyoaki, Homma, Akihiro, Yoshimoto, Seichi, and Hasegawa, Yasuhisa

Subjects
MINIMALLY invasive procedures, SENTINEL lymph nodes, INDOCYANINE green, ONCOLOGIC surgery, SURGERY
Abstract

Background: Sentinel node navigation surgery using indocyanine green (ICG‐SNNS) can be performed in the operation room. The combination of minimally invasive transoral surgery (TOS) with ICG‐SNNS can provide functional preservation options for both primary lesions and lymph node (LN) metastasis. This multicenter feasibility study of this strategy was conducted in Japan. Methods: Patients with clinical T1 or T2, N0 oropharyngeal, hypopharyngeal, or supraglottic cancer were enrolled. The identification rate of sentinel nodes, delayed cervical LN metastasis in 2 years, and survival rate were assessed. Results: Twenty‐two patients (10 oropharynx, 8 hypopharynx, 4 supraglottic cancer) were enrolled. The identification rate was 100%. One case had delayed nodal metastasis. The accuracy was 95.5%, sensitivity was 75%, and specificity was 100%. The 5‐year disease‐specific survival was 100%, overall survival was 72.3%, and disease‐free survival was 60.5%. Conclusions: The combination of TOS with ICG‐SNNS is feasible as a minimally invasive strategy and has favorable oncological outcomes. [ABSTRACT FROM AUTHOR]

Published
2020
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13. Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.

Author

Khan, Khurram, Araki, Koji, Daiyou Wang, Guayan Li, Xin Li, Jie Zhang, Weizheng Xu, Hoover, Randall K., Lauter, Susan, O'Malley, Jr., Bert, Lapidus, Rena G., and Daqing Li

Subjects
HEAD & neck cancer, POLY(ADP-ribose) polymerase, MEDICAL radiology, MEDICAL electronics
Abstract

Background In this study, we tested the ability of a novel poly(adenosine diphosphate ribose) polymerase (PARP) inhibitor, 10-(4-methyl-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-benzo[de]-anthracen-3-one (GPI-15427), to enhance the effect of radiotherapy in a xenograft model of human head and neck squamous cell carcinoma (HNSCC). Methods Human xenograft HNSCC tumors were established in female nude mice: animals were treated with orally administered GPI-15427 at varied doses prior to tumor irradiation. In vitro and in vivo apoptosis analyses and neutral single-cell gel electrophoresis (comet) assay were performed, with the “tail moment” calculated to evaluate DNA double-strand break damage. Results Orally administered GPI-15427 given before radiation therapy significantly reduced tumor volume, and cells demonstrated significantly elevated mean tail moments (indicative of DNA damage) and enhanced apoptosis both in vitro and in vivo, compared with radiation-alone and control groups. Conclusions Use of the PARP-1 inhibitor GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC. © 2009 Wiley Periodicals, Inc. Head Neck, 2010 [ABSTRACT FROM AUTHOR]

Published
2010
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