1. Spatial aspects of pain modulation are not disrupted in adolescents with migraine
- Author
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Scott W. Powers, Robert C. Coghill, Priya L. Thomas, Leigh A. Chamberlin, Christopher D. King, Andrew D. Hershey, Hadas Nahman-Averbuch, Victor J. Schneider, and James Peugh
- Subjects
Male ,Nociception ,medicine.medical_specialty ,Adolescent ,Migraine Disorders ,Test stimulus ,Stimulus (physiology) ,Audiology ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Inhibitory control ,medicine ,Humans ,030212 general & internal medicine ,Child ,Pain Measurement ,Pain modulation ,Leg ,business.industry ,medicine.disease ,Nociceptive processing ,Pathophysiology ,Neurology ,Migraine ,Conditioned pain modulation ,Case-Control Studies ,Superficial Back Muscles ,Female ,Neurology (clinical) ,business ,Neck ,030217 neurology & neurosurgery - Abstract
OBJECTIVE To compare spatial pain modulation capabilities between adolescents with and without migraine. BACKGROUND Conditioned pain modulation (CPM) responses at the leg are similar in adolescents with versus without migraine. However, the anatomical region of testing may affect spatial pain modulation capabilities as differences in nociceptive processing between patients with migraine and healthy controls are found in local areas that are near the site of clinical pain but not in nonlocal areas. This study aimed to examine spatial pain modulation capabilities tested by the CPM paradigm using test stimulus applied to a local body area. METHODS Nineteen adolescents with migraine (age 14.9 ± 2.3, mean ± SD; 16 female) and 20 healthy adolescents (age 13.8 ± 2.5, mean ± SD; 16 female) completed this case-control study at Cincinnati Children's Hospital Medical Center. Pressure pain thresholds (PPT) were assessed at the trapezius before and during immersion of the foot in a cold water bath (8°C). RESULTS In the migraine group (146.0 ± 79.1, mean ± SD), compared to healthy controls (248.0 ± 145.5, mean ± SD), significantly lower PPT (kilopascal) values were found (estimate = 124.28, 95% CI: 58.98, 189.59, p
- Published
- 2020
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