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A study conducted at Allama Iqbal Medical College in Lahore, Pakistan, explored the protective effects of flax seed oil on acetaminophen-induced toxicity in the renal cortex of albino rats. Acetaminophen is known for its analgesic and antipyretic properties, but overdosing or misuse can be harmful to the liver and kidneys. The research found that flax seed oil had an antioxidant effect that helped prevent damage to the kidneys caused by acetaminophen. The study concluded that acetaminophen is nephrotoxic, but flax seed oil can ameliorate its effects in rats. [Extracted from the article]

A recent study conducted by researchers at National Taiwan University Hospital and National Taiwan University College of Medicine evaluated the skin and immunological responses to a new dermal injectable collagen with lidocaine. The study compared this new filler to a commercially available traditional filler. The results showed that hypersensitivity reactions were lower with the new filler, indicating its safe use for nasolabial fold correction without the need for pretreatment skin testing. The study also found that most adverse effects were resolved or under control within 52 weeks. This research provides valuable insights for individuals considering dermal filler treatments. [Extracted from the article]

A recent report from the College of Medicine and Health Sciences discusses the hepatoprotective effects of Phytolacca dodecandra (L' Herit) methanol root extract on acetaminophen-induced liver injury in rats. The study found that the extract reversed the increase in liver enzymes, total bilirubin, low-density lipoprotein, and triglycerides caused by acetaminophen administration. Additionally, the extract demonstrated a dose-dependent hepatoprotective effect. The researchers concluded that Phytolacca dodecandra methanol root extract protected the liver from acetaminophen-induced injury. [Extracted from the article]

Researchers at the Department of Zoology in Kerala, India have conducted a study on the protective role of the leaf petiole of the Artocarpus heterophyllus Lam. plant in experimental hepatotoxicity. The study found that the methanol extract of Artocarpus heterophyllus showed the highest antioxidant activity, increasing the levels of antioxidant enzymes in the liver of rats treated with acetaminophen. The study suggests that the leaf petiole of Artocarpus heterophyllus could potentially be used in the treatment of liver disease due to its antioxidant properties. The research has been published in the Indian Journal of Pharmaceutical Sciences. [Extracted from the article]

Researchers from King Abdulaziz University in Saudi Arabia have published a study on the potential therapeutic effects of a kaempferol derivative called KSG in mitigating acetaminophen-induced hepatotoxicity. The study found that KSG pretreatment reduced liver damage and oxidative stress, suppressed inflammation, and inhibited apoptosis in mice with acute liver injury caused by acetaminophen overdose. The researchers also discovered that KSG modulated the Nrf2/NF-kB and JNK/ASK-1/caspase-3 signaling pathways, which are involved in liver injury. These findings suggest that KSG could be a promising candidate for the treatment of acute liver injury. [Extracted from the article]

Researchers from Beijing University of Technology have developed a new catalyst, called DEMAS200, based on electrolytic manganese anode slime (EMAS), which can activate peroxymonosulfate (PMS) in the degradation of acetaminophen (APAP). The DEMAS200/PMS system was found to effectively degrade various types of refractory organic matter, with 20 mg/L of APAP being removed within 4 minutes. The study also proposed a radical activation mechanism based on PMS, with adsorbed hydroxyl radicals (center dot OHads) identified as the major reactive oxygen species (ROS) involved. The research was published in the Chemical Engineering Journal and has been peer-reviewed. [Extracted from the article]

Researchers at the Altamash Institute of Dental Medicine conducted a study to compare the effectiveness of two different anesthetic techniques in patients with irreversible pulpitis. The study involved 150 patients who were randomly assigned to receive either an inferior mandibular nerve block with lidocaine infiltration or buccal infiltration of 4% articaine. The results showed that the buccal infiltration of articaine had a significantly higher success rate compared to the lidocaine infiltration. The researchers concluded that buccal infiltration of articaine can be a good alternative for managing pain in patients with irreversible pulpitis. [Extracted from the article]

A study conducted at IPB University in Indonesia examined the potential hepatoprotective effects of dates extract (Phoenix dactylifera) in mice. The study involved five groups of mice, including a positive control group, a negative control group, and three treatment groups. The mice in the treatment groups were given different volumes of dates extract orally for 20 days and then induced with acetaminophen for 3 days. Blood tests showed that the group with the highest volume of dates extract had the lowest level of liver damage. The study concluded that dates extract has the potential to be a hepatoprotective agent. [Extracted from the article]

Researchers from Tehran University of Medical Sciences conducted a study on the therapeutic potential of the aqueous extract of Berberis vulgaris (BV) and Berberis integerrima (BI) fruits against acetaminophen-induced hepatotoxicity in mice. The study found that the administration of BV and BI extracts ameliorated the toxic effects of acetaminophen on the liver in a dose-dependent manner. The extracts were found to have hepatoprotective effects, potentially due to their antioxidant properties. This research provides evidence for the potential use of these medicinal plants in protecting against liver damage. [Extracted from the article]

Researchers from Chang Gung Memorial Hospital in Taiwan have conducted a study on the hepatoprotective effect of stachydrine, a bioactive alkaloid derived from Leonurus heterophyllus, in a mouse model of acetaminophen-induced liver injury. The study found that stachydrine treatment reduced liver damage by decreasing inflammatory response, inhibiting the ERK and AKT pathways, and regulating the expression of macrophage-stimulating proteins. These findings suggest that stachydrine may be a promising target for preventing liver damage caused by acetaminophen overdose. The research was supported by the National Science Council and Chang Gung Memorial Hospital. [Extracted from the article]

Researchers at "Dunarea de Jos" University of Galati in Romania conducted a study on the antioxidant and hepatoprotective potential of berberine (BBR) and silymarin (SM) on acetaminophen-induced toxicity in Cyprinus carpio L. (common carp). The study aimed to investigate the beneficial properties of BBR and SM and their association with liver function using fish as in vivo models. The results showed that the inclusion of SM and BBR, either alone or in combination, reduced the serum contents of total cholesterol, triglyceride, and alanine transaminase. Both supplements demonstrated hepatoprotective activity against acetaminophen-induced hepatotoxicity, with BBR showing particularly strong effects. The study suggests that the combination of SM and BBR can modulate the immune system and alleviate oxidative stress after acetaminophen exposure. [Extracted from the article]

A recent study conducted by researchers from Cheeloo College of Medicine in China has found that mitochondrial dysfunction plays a crucial role in acute liver injury caused by an overdose of acetaminophen (APAP). The study discovered that the activation of the mitochondrial unfolded protein response (UPRmt) is involved in maintaining mitochondrial quality control and regulating gene expression. The researchers also found that the abnormal aggregation of TDP-43 in mitochondria contributes to the activation of UPRmt. Additionally, the study revealed that calpain-mediated cleavage of TDP-43 promotes its accumulation in mitochondria, leading to the activation of UPRmt. The researchers concluded that the induction of UPRmt contributes to the recovery of mitochondrial function and protects against APAP-induced liver injury. [Extracted from the article]

A recent study conducted by the Faculty of Veterinary Science and Animal Husbandry explored the potential of Bergenia ciliata (Haw.) Sternb. extract in mitigating drug-induced liver and kidney damage in rats. The extract, derived from the rhizome of the medicinal plant, demonstrated dose-dependent protective effects against acetaminophen-induced toxicity. The study found that the extract restored antioxidant parameters, decreased biomarkers of damage, and reversed histopathological alterations in the liver and kidneys. These findings suggest that Bergenia ciliata extract has potential therapeutic uses in the future. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital investigated the effects of lidocaine on cognitive function in rats with cognitive dysfunction. The study found that lidocaine had antioxidative stress, anti-inflammatory, and nerve-protective effects. Rats treated with lidocaine showed reduced cognitive impairment compared to the control group, and this improvement was attributed to the anti-inflammatory and antioxidative stress mechanisms of lidocaine in combination with CRMP2 antiphosphorylation. These findings suggest that lidocaine may have potential therapeutic benefits for cognitive dysfunction. [Extracted from the article]

Mice were humanely put to death 24 hours after the last dose and serum alanine aminotransferase and aspartate aminotransferase activities, total bilirubin and protein levels, reduced glutathione, superoxide dismutase, malondialdehyde, catalase, and nitrite tissue levels were assessed. Keywords: Acetanilides; Alanine; Amino Acids; Aminotransferase; Anilides; Bile Pigments; Bilirubin; Biological Factors; Catalase; Dismutase; Enzymes and Coenzymes; Enzymology; Glutathione; Oligopeptides; Peptides; Risk and Prevention EN Acetanilides Alanine Amino Acids Aminotransferase Anilides Bile Pigments Bilirubin Biological Factors Catalase Dismutase Enzymes and Coenzymes Enzymology Glutathione Oligopeptides Peptides Risk and Prevention 3741 3741 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on acetanilides is now available. In curative treatment, C quadrangularis and J gossypiifolia (50 and 100 mg/kg) significantly (P < 0.05) reduced mean (SEM) body weight loss (16.67% [7.16%] and 1.25% [0.51%], respectively), serum alanine aminotransferase activity (17.62% and 11.14%, respectively), bilirubin level (29.62% and 49.14%, respectively) compared with acetaminophen group, and J gossypiifolia normalized serum total protein level. [Extracted from the article]

Keywords: Hangzhou; People's Republic of China; Asia; Life Science; Acetanilides; Anilides; Connective Tissue Cells; Health and Medicine; Immunology; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Phagocytes EN Hangzhou People's Republic of China Asia Life Science Acetanilides Anilides Connective Tissue Cells Health and Medicine Immunology Macrophages Mononuclear Phagocyte System Myeloid Cells Phagocytes 2763 2763 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Life Science have been published. Moreover, SA treatment reduced the secondary liver cell damage aggravated by the conditioned medium (CM) taken from LPS/ATP-treated macrophages. [Extracted from the article]

The activity against acetaminophen toxicity was evaluated using different protocols, i.e., pre-treatment, co-treatment, and post-treatment of the cells with acetaminophen and the plant extracts." The news correspondents obtained a quote from the research from University of Brasilia: "HepG2 cell viability after treatment with acetaminophen was 39.61 (+-) 5.59% of viable cells. [Extracted from the article]

Keywords: Providence; State:Rhode Island; United States; North and Central America; Acetanilides; Anilides; Dermatology; Health and Medicine; Hypopigmentation; Pigmentation Disorders; Risk and Prevention; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Vitiligo EN Providence State:Rhode Island United States North and Central America Acetanilides Anilides Dermatology Health and Medicine Hypopigmentation Pigmentation Disorders Risk and Prevention Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Vitiligo 2643 2643 1 10/09/23 20231013 NES 231013 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Skin Diseases and Conditions - Vitiligo have been published. In NHS, a total of 161 vitiligo cases were identified during a follow-up of 571,724 person-years; in HPFS, a total of 183 vitiligo cases were identified during a follow-up of 680,313 person-years. [Extracted from the article]

According to the news reporters, the research concluded: "Eel oil has hepatoprotective activity by inhibiting SGPT, total bilirubin, MDA, and increasing GSH levels in rats." Keywords: Acetanilides; Anilides; Bile Pigments; Bilirubin; Biological Factors; Enzymes and Coenzymes; Health and Medicine; Risk and Prevention; Transaminases EN Acetanilides Anilides Bile Pigments Bilirubin Biological Factors Enzymes and Coenzymes Health and Medicine Risk and Prevention Transaminases 7763 7763 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on agriculture are discussed in a new report. [Extracted from the article]

Acetanilides, Anilides, Apoptosis, Apoptosis Regulatory Proteins, Caspases, Cellular Physiology, Cytokines, Health and Medicine, Inflammation, Intercellular Signaling Peptides and Proteins, Interleukins, Intracellular Signaling Peptides and Proteins Keywords: Acetanilides; Anilides; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cellular Physiology; Cytokines; Health and Medicine; Inflammation; Intercellular Signaling Peptides and Proteins; Interleukins; Intracellular Signaling Peptides and Proteins EN Acetanilides Anilides Apoptosis Apoptosis Regulatory Proteins Caspases Cellular Physiology Cytokines Health and Medicine Inflammation Intercellular Signaling Peptides and Proteins Interleukins Intracellular Signaling Peptides and Proteins 4427 4427 1 07/03/23 20230707 NES 230707 2023 JUL 7 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on apoptosis. Keywords for this news article include: Jazan University, Jazan, Saudi Arabia,, Caspases, Cytokines, Acetanilides, Inflammation, Interleukins, Cellular Physiology, Health and Medicine, Apoptosis Regulatory Proteins, Intercellular Signaling Peptides and Proteins, Intracellular Signaling Peptides and Proteins. [Extracted from the article]

Acetanilides, Anilides, Health and Medicine, Inflammation, Inflammation Research Keywords: Acetanilides; Anilides; Health and Medicine; Inflammation; Inflammation Research EN Acetanilides Anilides Health and Medicine Inflammation Inflammation Research 6408 6408 1 06/26/23 20230630 NES 230630 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on inflammation research. The method was successfully applied to evaluate AT7519 and APAP levels 20 h post AT7519 (10 mg/mg) in C57Bl6J wild type mouse serum treated with either vehicle or APAP. [Extracted from the article]

Keywords: Shaanxi; People's Republic of China; Asia; Life Science; Acetanilides; Anilides; Protein Expression; Proteomics; Risk and Prevention EN Shaanxi People's Republic of China Asia Life Science Acetanilides Anilides Protein Expression Proteomics Risk and Prevention 3612 3612 1 06/26/23 20230630 NES 230630 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Life Science. The news correspondents obtained a quote from the research from the Shaanxi University of Technology, "We used immunohistochemistry to detect CYP2E1, Nrf2, and Keap1 protein expression in the liver. Shaanxi, People's Republic of China, Asia, Life Science, Acetanilides, Anilides, Protein Expression, Proteomics, Risk and Prevention. [Extracted from the article]

Keywords: Acetanilides; Anilides; Carbon Tetrachloride; Chemicals; Chlorinated Hydrocarbons; Hepatocytes; Metabolism; Physiology; Risk and Prevention EN Acetanilides Anilides Carbon Tetrachloride Chemicals Chlorinated Hydrocarbons Hepatocytes Metabolism Physiology Risk and Prevention 4496 4496 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on metabolism have been presented. Acetanilides, Anilides, Carbon Tetrachloride, Chemicals, Hepatocytes, Metabolism, Physiology, Risk and Prevention, Chlorinated Hydrocarbons. [Extracted from the article]

Keywords: Bucharest; Romania; Europe; Applied Sciences; Science; Acetanilides; Anilides; Biochemicals; Biochemistry; Chemicals; Risk and Prevention EN Bucharest Romania Europe Applied Sciences Science Acetanilides Anilides Biochemicals Biochemistry Chemicals Risk and Prevention 5956 5956 1 05/02/23 20230505 NES 230505 2023 MAY 5 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Science - Applied Sciences is now available. Bucharest, Romania, Europe, Applied Sciences, Science, Acetanilides, Anilides, Biochemicals, Biochemistry, Chemicals, Risk and Prevention. [Extracted from the article]

Keywords: Acetanilides; Anilides; Health and Medicine; Medical Science; Risk and Prevention EN Acetanilides Anilides Health and Medicine Medical Science Risk and Prevention 4645 4645 1 05/02/23 20230505 NES 230505 2023 MAY 5 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on medical science is the subject of a new report. According to the news reporters, the research concluded: "Hydroalcoholic extract of Phlomis cancellata had a protective role in improving acute acetaminophen-induced hepatotoxicity.". [Extracted from the article]

Keywords: Acetanilides; Anilides; Cellular Structures; Cytoplasm; Cytoplasmic Structures; Health and Medicine; Intracellular Space; Mitochondria; Organelles; Subcellular Fractions EN Acetanilides Anilides Cellular Structures Cytoplasm Cytoplasmic Structures Health and Medicine Intracellular Space Mitochondria Organelles Subcellular Fractions 6118 6118 1 04/24/23 20230428 NES 230428 2023 APR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on agriculture is now available. Anilides, Cellular Structures, Cytoplasm, Cytoplasmic Structures, Health and Medicine, Intracellular Space, Mitochondria, Organelles, Subcellular Fractions, Acetanilides. [Extracted from the article]

Through the regulation of mitochondrial biogenesis, reduction of ROS and prevention of increment psi m loss, DEX attenuates the SH-SY5Y cell apoptosis elicited by lidocaine." Keywords: Chongqing; People's Republic of China; Asia; Acetanilides; Apoptosis; Caspase; Cellular Physiology; Enzymes and Coenzymes; Health and Medicine; Lidocaine; Risk and Prevention EN Chongqing People's Republic of China Asia Acetanilides Apoptosis Caspase Cellular Physiology Enzymes and Coenzymes Health and Medicine Lidocaine Risk and Prevention 2659 2659 1 04/17/23 20230421 NES 230421 2023 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Cellular Physiology - Apoptosis are presented in a new report. [Extracted from the article]

Keywords: Taoyuan; Taiwan; Asia; Acetanilides; Anilides; DNA-Binding Proteins; Enzymes and Coenzymes; Flavoproteins; NADPH Oxidase; NF-kappa B; Nuclear Proteins; Oxidase; Proteins; Risk and Prevention; Transcription Factors EN Taoyuan Taiwan Asia Acetanilides Anilides DNA-Binding Proteins Enzymes and Coenzymes Flavoproteins NADPH Oxidase NF-kappa B Nuclear Proteins Oxidase Proteins Risk and Prevention Transcription Factors 6264 6264 1 03/27/23 20230331 NES 230331 2023 MAR 31 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Proteins - Transcription Factors is now available. For more information on this research see: Role of Nadph Oxidase-derived Ros-mediated Il-6/stat3 and Mapk/nf-kappa B Signaling Pathways In Protective Effect of Corilagin Against Acetaminophen-induced Liver Injury In Mice. [Extracted from the article]

Western blotting and TUNEL analysis also revealed CF-inhibited cell apoptosis-related protein expression (Bcl2 and caspase-3/9 proteins)." Keywords: Yunnan; People's Republic of China; Asia; Acetanilides; Anilides; Caspase; Caspases; Cysteine Endopeptidases; DNA-Binding Proteins; Enzymes and Coenzymes; NF-kappa B; Nuclear Proteins; Peptide Hydrolases; Proteins; Risk and Prevention; Transcription Factors EN Yunnan People's Republic of China Asia Acetanilides Anilides Caspase Caspases Cysteine Endopeptidases DNA-Binding Proteins Enzymes and Coenzymes NF-kappa B Nuclear Proteins Peptide Hydrolases Proteins Risk and Prevention Transcription Factors 4810 4810 1 03/23/23 20230324 NES 230324 2023 MAR 24 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Proteins - Transcription Factors have been published. [Extracted from the article]

Acetanilides, Enzymes and Coenzymes, Flavoproteins, Anilides, NADPH Oxidase, Proteins, Risk and Prevention, Oxidase Keywords: Acetanilides; Anilides; Enzymes and Coenzymes; Flavoproteins; NADPH Oxidase; Oxidase; Proteins; Risk and Prevention EN Acetanilides Anilides Enzymes and Coenzymes Flavoproteins NADPH Oxidase Oxidase Proteins Risk and Prevention 3670 3670 1 03/23/23 20230317 NES 230317 2023 MAR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in flavoproteins. [Extracted from the article]