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Although research has documented the endemic nature of psychological distress among homeless people, little is known about the variation of and change in distress when psychiatric disabilities and housing status are considered. Using longitudinal data from a homeless sample, the author examined the pattern of distress across three groups--people with serious mental illness (SMI), people with drug or alcohol problem, and people with neither diagnosis. Distress symptoms were most pervasive and persistent among people with SMI. The effect of housing status on distress differed across the three groups and was statistically significant for people with no psychiatric diagnosis. [ABSTRACT FROM AUTHOR]