1. A significance of school screening electrocardiogram in the patients with ventricular noncompaction
- Author
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Keiichi, Hirono, Nariaki, Miyao, Masao, Yoshinaga, Eiki, Nishihara, Kazushi, Yasuda, Shigeru, Tateno, Mamoru, Ayusawa, Naokata, Sumitomo, Hitoshi, Horigome, Mari, Iwamoto, Hideto, Takahashi, Seiichi, Sato, Shigetoyo, Kogaki, Seiko, Ohno, Tadayoshi, Hata, Daisuke, Hazeki, Naomi, Izumida, Masami, Nagashima, Kunio, Ohta, Nobuo, Tauchi, Hiroya, Ushinohama, Shozaburo, Doi, Fukiko, Ichida, and Study group on childhood cardiomyopathy in Japan
- Subjects
Diagnostic Screening Programs ,Male ,medicine.medical_specialty ,Adolescent ,Cardiomyopathy ,030204 cardiovascular system & hematology ,Risk Assessment ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Predictive Value of Tests ,Internal medicine ,Prevalence ,Humans ,Medicine ,030212 general & internal medicine ,Child ,Retrospective Studies ,School Health Services ,J wave ,Isolated Noncompaction of the Ventricular Myocardium ,Ejection fraction ,business.industry ,Proportional hazards model ,Age Factors ,Arrhythmias, Cardiac ,Retrospective cohort study ,Odds ratio ,Prognosis ,medicine.disease ,Heart Disease Risk Factors ,Cohort ,Cardiology ,Heart Transplantation ,Left ventricular noncompaction ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy and is associated with high morbidity and mortality. However, the role and significance of school screening for LVNC have not been fully elucidated. In this multicenter, retrospective cohort study, a total of 105 children with LVNC were included from 2000 to 2017. At the initial presentation, 44 patients (41.9%) were diagnosed by school screening. One (1.0%) patient underwent heart transplantation and four (3.8%) patients died during the study. Electrocardiogram data showed a high prevalence of fragmented QRS (33.4%) and J wave (15.7%). Treatments were needed in eight (18.2%) patients who were detected by school screening. The multivariable proportional hazards model showed T-wave abnormality on electrocardiogram in first graders was independent risk factors for major adverse cardiac events (odds ratio 4.94, p value = 0.0007). Moreover, dilation of the left atrium on chest X-ray and low ejection fraction on echocardiogram at the initial treatment were independent risk factors for treatment (odds ratio 1.7 × 107 and 22.3, p = 0.0362 and 0.0028, respectively). This study is the first report focusing on school screening in a large pediatric cohort with LVNC. With the use of abnormalities in electrocardiogram, school screening may be a good detector of and predictor for LVNC.
- Published
- 2020
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