1. Measuring Myocardial Energetics with Cardiovascular Magnetic Resonance Spectroscopy.
- Author
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Sourdon J, Lewsey SC, Schär M, and Weiss RG
- Subjects
- Heart Failure diagnosis, Humans, Energy Metabolism, Heart Failure metabolism, Magnetic Resonance Spectroscopy methods, Myocardium metabolism
- Abstract
The heart has the highest energy demands per gram of any organ in the body and energy metabolism fuels normal contractile function. Metabolic inflexibility and impairment of myocardial energetics occur with several common cardiac diseases, including ischemia and heart failure. This review explores several decades of innovation in cardiac magnetic resonance spectroscopy modalities and their use to noninvasively identify and quantify metabolic derangements in the normal, failing, and diseased heart. The implications of this noninvasive modality for predicting significant clinical outcomes and guiding future investigation and therapies to improve patient care are discussed., Competing Interests: Disclosure The authors acknowledge support from the National Institutes of Health (HL61912, HL63030, HL149742, AG063661) and from the Clarence Doodeman Endowment in Cardiology at Johns Hopkins., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
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