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Your search keyword '"Angela M. Farrelly"' showing total 2 results
Start Over Author "Angela M. Farrelly" Journal heliyon
2 results on '"Angela M. Farrelly"'

1. Design, synthesis and evaluation of novel 2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one based chalcones as cytotoxic agents

Author

Julie Jean, David S. Farrell, Angela M. Farrelly, Sinead Toomey, and James W. Barlow

Subjects
Cancer research, Pharmaceutical chemistry, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

We designed and synthesised a series of novel chalcones, incorporating the heterocyclic framework of 2,2-dimethyl-2,3-dihydro-4(1H)-quinolinone, which was prepared via Sonogashira coupling of a substituted orthoaniline under aqueous conditions using Pd catalysis followed by acid-mediated cyclisation. The compounds were screened against the NCI-N87 and DLD-1 cancer cell lines, with most compounds showing low micromolar cytotoxic activity.

Published
2018
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2. Design, synthesis and evaluation of novel 2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one based chalcones as cytotoxic agents

Author

Sinead Toomey, James W. Barlow, Julie Jean, Angela M. Farrelly, and David S. Farrell

Subjects
Multidisciplinary, Aqueous solution, 010405 organic chemistry, Chemistry, Sonogashira coupling, Cancer research, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Article, 0104 chemical sciences, Catalysis, Design synthesis, Cytotoxic T cell, lcsh:H1-99, Cancer cell lines, lcsh:Social sciences (General), Cytotoxicity, lcsh:Science (General), Pharmaceutical chemistry, lcsh:Q1-390
Abstract

We designed and synthesised a series of novel chalcones, incorporating the heterocyclic framework of 2,2-dimethyl-2,3-dihydro-4(1H)-quinolinone, which was prepared via Sonogashira coupling of a substituted orthoaniline under aqueous conditions using Pd catalysis followed by acid-mediated cyclisation. The compounds were screened against the NCI-N87 and DLD-1 cancer cell lines, with most compounds showing low micromolar cytotoxic activity.

Published
2018

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