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Influenza, an acute respiratory illness, remains a significant public health challenge, contributing substantially to morbidity and mortality worldwide. Its seasonal prevalence exhibits diversity across regions with distinct climates. This study aimed to explore the seasonal patterns of influenza and their correlation with meteorological and air pollution factors across six regions of Thailand. We conducted an analysis of monthly average temperature, relative humidity, precipitation, PM10, NO 2 , O 3 concentrations, and influenza incidence data from 2009 to 2019 using wavelet analysis. Our findings reveal inconsistent biannual influenza prevalence patterns throughout the study period. The biannual pattern emerged during 2010-2012 across all regions but disappeared during 2013-2016. However, post-2016, the biannual cycles resurfaced, with peaks occurring during the rainy and winter seasons in most regions, except for the southern region. Wavelet coherence reveals that relative humidity can be the main influencing factor for influenza incidence over a one-year period in the northern, northeastern, central, Bangkok-metropolitan, and eastern regions, not in the southern region during 2010-2012 and 2016-2018. Similarly, precipitation can drive the influenza incidence at the same period for the northeastern, central, Bangkok-metropolitan, and eastern regions. PM10 concentration can influence influenza incidence over a half-year period in the northeastern, central, Bangkok-metropolitan, and eastern regions of Thailand during certain years. These results enhance our understanding of the temporal dynamics of influenza seasonality influenced by weather conditions and air pollution over the past 11 years. Such knowledge is invaluable for resource allocation in clinical settings and informing public health strategies, particularly in navigating Thailand's climatic complexities., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

The COVID-19 pandemic has significantly impacted public health and necessitated urgent actions to mitigate its spread. Monitoring and predicting the outbreak's progression have become vital to devise effective strategies and allocate resources efficiently. This study presents a novel approach utilizing Multivariate Long Short-Term Memory (LSTM) to analyze and predict COVID-19 trends in Central Thailand, particularly emphasizing the multi-feature selection process. To consider a comprehensive view of the pandemic's dynamics, our research dataset encompasses epidemiological, meteorological, and particulate matter features, which were gathered from reliable sources. We propose a multi-feature selection technique to identify the most relevant and influential features that significantly impact the spread of COVID-19 in the region to enhance the model's performance. Our results highlight that relative humidity is the key factor driving COVID-19 transmission in Central Thailand. The proposed multi-feature selection technique significantly improves the model's accuracy, ensuring that only the most informative variables contribute to the predictions, avoiding the potential noise or redundancy from less relevant features. The proposed LSTM model demonstrates its capability to forecast COVID-19 cases, facilitating informed decision-making for public health authorities and policymakers., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier Ltd.)

Mass vaccination has proven to be an effective control measure for mitigating the transmission of infectious diseases. Throughout history, various vaccination strategies have been employed to control infections and terminate outbreaks. In this study, we utilized the transmission of COVID-19 as a case study and constructed a stochastic age-structured compartmental model to investigate the effectiveness of different vaccination strategies. Our analysis focused on estimating the outbreak extinction probability under different vaccination scenarios in both homogeneous and heterogeneous populations. Notably, we found that population heterogeneity can enhance the likelihood of outbreak extinction at varying levels of vaccine coverage. Prioritizing vaccinations for individuals with higher infection risk was found to maximize outbreak extinction probability and reduce overall infections, while allocating vaccines to those with higher mortality risk has been proven more effective in reducing deaths. Moreover, our study highlighted the significance of booster doses as the vaccine effectiveness wanes over time, showing that they can significantly enhance the extinction probability and mitigate disease transmission., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)