Search

Fourier Transform Infrared Spectroscopy (FT-IR) and High-Performance Liquid Chromatography (HPLC) could be applied to study the provenance of wood, specifically the differentiation of wood resources, as well as the identification of chemical compounds that are connected to the changes that occur in wood as a result of drying treatments. To test this hypothesis, the bark of silver fir (Abies alba Mill.) from trees belonging to seven different geographical provenances was studied, using samples dried at three different temperatures (60, 80, and 100 °C). FT-IR spectroscopy revealed different band assignments in the mid-infrared region depending on fir provenances, whereas the vibrational bands of the biomass functional groups tended to shift to lower wavenumbers. Significant differences were identified between the chemical compounds in the bark depending on the provenances. The largest proportion of the total phenolics was represented by the epicatechin gallate, epicatechin, catechin, and procyanidin dimer B1. Exploratory data analysis was performed using principal component analysis (PCA), hierarchical clustering, and Pearson correlations. This allowed a comparative evaluation of the samples and interpret the findings according to the geographical provenances, respectively ecological conditions in the areas of origin, but also the influence of the drying temperatures of the samples on chemical compounds. The precipitation in the areas of origin decreased total phenolics in silver fir bark samples, and total phenolics differed not only due to the geographic provenance, but also due to drying temperature.

Polygalae radix (PR) is a famous herbal medicine obtained by drying the root of Polygala tenuifolia Willd., one of the traditional Chinese medicines (TCM) that can be used for healthy food. There are three main processed methods of PR, including removing the xylem of roots (Polygalae Cortex, PC), frying PC with licorice (LP), and frying PC with honey (HP). While processing is believed to enhance efficacy and reduce toxicity, it is crucial to understand the differences in chemical composition and biological activities between crude and processed PR. This study used ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) combined with multivariate statistical analysis to analyze the chemical profiles and differences between the crude and processed products. Total polyphenol contents (TPC), total flavonoid contents (TFC), total saponin contents (TSC) and antioxidant activity of the processed and crude PR were also investigated. A total of 131 chemical compounds, including 42 saponins, 44 oligosaccharide esters, 25 xanthones, 2 organic acids, 3 Carbohydrates, and 15 components detected in auxiliary materials, were detected in all samples. Notably, PC exhibited significant changes among the three processed products, with the content of 62 compounds being higher. Processing of licorice (LP) and honey (HP) decreased the content of several compounds due to temperature and moisture influences. Comprehensive comparison of the antioxidant capacity of crude and processed PR showed that the antioxidant capacity of PC was higher than that of PR, HP, and LP. Our results can provide a scientific basis for further developing and applying P. tenuifolia resources.

Numerous studies demonstrate a strong intrinsic relationship between the boiling and melting temperatures, among other chemical properties, of chemical compounds and pharmaceutical and their molecular structures. Using topological indices, researchers can learn more about the physical traits, chemical stability, and bioactivities of these chemical molecular structures. Topological indices on the chemical structure of chemical materials and drugs are investigated in order to make up for the absence of chemical experiments and provide a theoretical basis for the manufacture of medications and chemical materials. According to well-known degree-based topological indices, the chemical structures of drugs used to treat hepatitis (A, B, C, D, and E) are assessed in this study. The atoms are thought of as the vertices of a graph, and the borders that separate them are thought of as the edges. Using degree-based topological indices, a quantitative structure-property relationship (QSPR) investigation was conducted to predict the physical properties of 16 hepatitis medications. These topological indices link the chemical structure to specific physical characteristics, such as the surface tension of hepatitis medication molecules and molecular weight, enthalpy, boiling point, density, vapor pressure, and logP. Using their molecular structures, the study's drugs are represented as molecular graphs, and 14 topological indices are computed.

Medicinal herbs are being widely accepted as alternative remedies for preventing various diseases especially in India and other Asian countries. However, most plant-based herbal medicines are not yet being scientifically accepted worldwide. “Tinospora cordifolia (Willd.) Miers ex Hook.F. & Thomson”, one of the most promising plant species of Tinospora known as “Giloy” or Guduchi that is used in several traditional medicines in treating diseases e.g., metabolic and immune disorders, diabetes, heart diseases, cancer, and infectious diseases, has been widely investigated. Varieties of bioactive phytochemical constituents isolated from the stem, root and whole plant of T. cordifolia have been identified. In the last two decades, the diverse pharmacological activities of T. cordifolia have been continuously studied. Due to its therapeutic efficacy in immune modulation, it could be effective in viral and other diseases treatment as well. A medicinal plant could be well-suited not only for the treatment of target site but also for boosting the body's immune system. As an alternate source of medication, medicinal herbs are continuously showing better compatibility with the human body with minimal side effects than other therapies. Keeping this in mind, the present review highlights the pharmacological potential of T. cordifolia against various diseases.

Medicinal herbs are being widely accepted as alternative remedies for preventing various diseases especially in India and other Asian countries. However, most plant-based herbal medicines are not yet being scientifically accepted worldwide. " Tinospora cordifolia (Willd.) Miers ex Hook.F. & Thomson", one of the most promising plant species of Tinospora known as "Giloy" or Guduchi that is used in several traditional medicines in treating diseases e.g., metabolic and immune disorders, diabetes, heart diseases, cancer, and infectious diseases, has been widely investigated. Varieties of bioactive phytochemical constituents isolated from the stem, root and whole plant of T. cordifolia have been identified. In the last two decades, the diverse pharmacological activities of T. cordifolia have been continuously studied. Due to its therapeutic efficacy in immune modulation, it could be effective in viral and other diseases treatment as well. A medicinal plant could be well-suited not only for the treatment of target site but also for boosting the body's immune system. As an alternate source of medication, medicinal herbs are continuously showing better compatibility with the human body with minimal side effects than other therapies. Keeping this in mind, the present review highlights the pharmacological potential of T. cordifolia against various diseases., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: None. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)

Numerous studies demonstrate a strong intrinsic relationship between the boiling and melting temperatures, among other chemical properties, of chemical compounds and pharmaceutical and their molecular structures. Using topological indices, researchers can learn more about the physical traits, chemical stability, and bioactivities of these chemical molecular structures. Topological indices on the chemical structure of chemical materials and drugs are investigated in order to make up for the absence of chemical experiments and provide a theoretical basis for the manufacture of medications and chemical materials. According to well-known degree-based topological indices, the chemical structures of drugs used to treat hepatitis (A, B, C, D, and E) are assessed in this study. The atoms are thought of as the vertices of a graph, and the borders that separate them are thought of as the edges. Using degree-based topological indices, a quantitative structure-property relationship (QSPR) investigation was conducted to predict the physical properties of 16 hepatitis medications. These topological indices link the chemical structure to specific physical characteristics, such as the surface tension of hepatitis medication molecules and molecular weight, enthalpy, boiling point, density, vapor pressure, and logP. Using their molecular structures, the study's drugs are represented as molecular graphs, and 14 topological indices are computed., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)