1. Sex differences in the correlation between white matter hyperintensity and 3-month outcome in acute stroke patients
- Author
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Junli Ren, Xia Zhang, Haobo Xie, Xinbo Zhou, Jiahan Xu, Haojie Qiu, Jielin Zhou, Wei Xie, Siqi Chen, Xin Lu, Yichuan Fan, Dehao Yang, and Guangyong Chen
- Subjects
Stroke ,White matter hyperintensities ,Outcome ,Sex difference ,Intravenous thrombolysis ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: The severity of white matter hyperintensities (WMH) has been shown to be an independent predictor of poor stroke outcome, but the effect of sex on this correlation has not been investigated further. Therefore, the purpose of our study was to assess whether there was a sex difference between the severity of WMH and poor stroke outcome. Methods: This retrospective study included 449 patients with acute ischemic stroke (AIS) who received intravenous thrombolysis. WMH severity was graded based on the Fazekas scale. The association between WMH severity and stroke outcome was explored through multivariable regression analyses in men and women. Results: Among women, when dividing WMH severity into tertiles, T3 (Fazekas scale >3) had a 5.334 times higher risk for unfavorable outcomes than T1 (Fazekas scale
- Published
- 2024
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