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Solution-based and solid-state reactions of copper(ii) compounds, 1,10-phenanthroline and l-threonine were investigated. Eight new ternary coordination compounds were obtained:[Cu(l-Thr)(H2O)(phen)]2SO4∙10H2O (1a∙10H2O), [Cu(l-Thr)(H2O) (phen)]2SO4∙4.3H2O (1a∙4.3H2O), {[Cu(μ-l-Thr)(phen)]2SO4∙3.5H2O}n (1b∙3.5H2O), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(CH3OH)(phen)]SO4∙2H2O∙CH3OH (1c∙2H2O∙CH3OH), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(CH3OH)(phen)]SO4∙4H2O (1c∙4H2O), [Cu(l-Thr)(CH3OH)(phen)]2SO4∙H2O (1d∙H2O), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(CH3OH)(phen)][Cu(SO4)(l-Thr)(phen)]HSO4∙H2O∙3CH3OH (1e·H2O·3CH3OH), [Cu(l-Thr)(H2O)(phen)][Cu(l-Thr)(phen)(py)]SO4 (1f) (phen = 1,10-phenanthroline, l-Thr = l-threoninate, py = pyridine). X-ray crystal structure analysis of the prepared ternary coordination compounds revealed extensive hydrogen bonding and π-interactions that link complex species, anions and solvent molecules into 3D architectures. The water/methanol solvent molecules are found in pockets and/or channels in seven solvates. ESR spectra of different types of compounds were also investigated. In all measured compounds the unpaired electron of the copper(II) ion is located in the dx2-y2 orbital which is in agreement with elongated square-pyramidal geometry. Compound 1a∙10H2O showed substantial cytotoxic activity toward human hepatocellular carcinoma (HepG2) and acute monocytic leukaemia (THP-1) cell lines.

Solution-based and solid-state reactions of copper(ii) compounds, 1,10-phenanthroline and l-threonine were investigated. Eight new ternary coordination compounds were obtained: [Cu(l-Thr)(H 2 O)(phen)] 2 SO 4 ∙10H 2 O ( 1a∙10H 2 O ), [Cu(l-Thr)(H 2 O) (phen)] 2 SO 4 ∙4.3H 2 O ( 1a∙4.3H 2 O ), {[Cu( μ -l-Thr)(phen)] 2 SO 4 ∙3.5H 2 O} n ( 1b∙3.5H 2 O ), [Cu(l-Thr)(H 2 O)(phen)][Cu(l-Thr)(CH 3 OH)(phen)]SO 4 ∙2H 2 O∙CH 3 OH ( 1c∙2H 2 O∙CH 3 OH ), [Cu(l-Thr)(H 2 O)(phen)][Cu(l-Thr)(CH 3 OH)(phen)]SO 4 ∙4H 2 O ( 1c∙4H 2 O) , [Cu(l-Thr)(CH 3 OH)(phen)] 2 SO 4 ) (phen = 1,10-phenanthroline, l-Thr = l-threoninate, py = pyridine). X-ray crystal structure analysis of the prepared ternary coordination compounds revealed extensive hydrogen bonding and π-interactions that link complex species, anions and solvent molecules into 3D architectures. The water/methanol solvent molecules are found in pockets and/or channels in seven solvates. ESR spectra of different types of compounds were also investigated. In all measured compounds the unpaired electron of the copper(II) ion is located in the d 2 O ( 1d∙H 2 O ), [Cu(l-Thr)(H 2 O)(phen)][Cu(l-Thr)(CH 3 OH)(phen)][Cu(SO 4 )(l-Thr)(phen)]HSO 4 ∙H 2 O∙3CH 3 OH ( 1e·H 2 O·3CH 3 OH ), [Cu(l-Thr)(H 2 O)(phen)][Cu(l-Thr)(phen)(py)]SO 4 ( 1f ) (phen = 1,10-phenanthroline, l-Thr = l-threoninate, py = pyridine). X-ray crystal structure analysis of the prepared ternary coordination compounds revealed extensive hydrogen bonding and π-interactions that link complex species, anions and solvent molecules into 3D architectures. The water/methanol solvent molecules are found in pockets and/or channels in seven solvates. ESR spectra of different types of compounds were also investigated. In all measured compounds the unpaired electron of the copper(II) ion is located in the d x2-y2 orbital which is in agreement with elongated square-pyramidal geometry. Compound 1a∙10H 2 O showed substantial cytotoxic activity toward human hepatocellular carcinoma (HepG2) and acute monocytic leukaemia (THP-1) cell lines., Competing Interests: The authors declare no conflict of interest., (© 2022 The Author(s).)