1. Juglanones A and B: Two Novel Tetralone Dimers from Walnut Pericarp (Juglans regia)
- Author
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Zhi-Peng Yuan, Xue-Hui Su, Hongjian Du, Cong-Ying Li, Bing Liang, Yu-Jiao Zhong, and Yanfang Li
- Subjects
biology ,Stereochemistry ,Organic Chemistry ,biology.organism_classification ,Biochemistry ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Tetralone ,Physical and Theoretical Chemistry ,Human cancer ,Juglans ,Tetralones ,Biological evaluation - Abstract
Two novel tetralone dimers, with an O-bridge, named juglanones A and B (1 and 2, resp.), were isolated from the AcOEt extract of walnut pericarps. These compounds are the first examples of O-bridged dimeric tetralones. Their structures were determined by spectroscopic methods, including HR-TOF-MS, and 1D- and 2D-NMR. Biological evaluation of these two isolates against a number of human cancer cell lines is also described.
- Published
- 2013
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