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27 results on '"Engert, Andreas"'

1. Human leukocyte antigen (HLA) class I expression on Hodgkin–Reed–Sternberg cells is an EBV‐independent major determinant of microenvironment composition in classic Hodgkin lymphoma.

Author

Müller‐Meinhard, Berit, Seifert, Nicole, Grund, Johanna, Reinke, Sarah, Yalcin, Fatih, Kaul, Helen, Borchmann, Sven, von Tresckow, Bastian, Borchmann, Peter, Plütschow, Annette, Richter, Julia, Engert, Andreas, Altenbuchinger, Michael, Bröckelmann, Paul J., and Klapper, Wolfram

Published
2024
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2. S218: CORRELATION BETWEEN PROGRESSION-FREE AND OVERALL SURVIVAL IN PATIENTS WITH CLASSICAL HODGKIN LYMPHOMA: A COMPREHENSIVE ANALYSIS OF INDIVIDUAL PATIENT DATA FROM RANDOMIZED GHSG TRIALS

Author

Bröckelmann, Paul, primary, Müller, Horst, additional, Gillessen, Sarah, additional, Jacob, Anne Sophie, additional, Momotow, Jesko, additional, Damaschin, Carla, additional, Ferdinandus, Justin, additional, Yang, Xiaoqin, additional, Fuchs, Michael, additional, Kobe, Carsten, additional, Eich, Hans T., additional, Engert, Andreas, additional, Borchmann, Peter, additional, and von Tresckow, Bastian, additional

Published
2023
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3. S236: HIGH-BREADTH SEQUENCING OF CIRCULATING TUMOR DNA IDENTIFIES NOVEL CLASSIFICATION OF HODGKIN LYMPHOMA

Author

Heger, Jan-Michel, primary, Mattlener, Julia, additional, Mammadova, Laman, additional, Sobesky, Sophia, additional, Cirillo, Melita, additional, Altmüller, Janine, additional, Kirst, Elisabeth, additional, Reinke, Sarah, additional, Klapper, Wolfram, additional, Bröckelmann, Paul J, additional, Ferdinandus, Justin, additional, Ullrich, Roland T, additional, Freihammer, Max, additional, Awerkiew, Sabine, additional, Lohmann, Mia, additional, Klein, Florian, additional, Nürnberg, Peter, additional, Hallek, Michael, additional, Engert, Andreas, additional, Borchman, Peter, additional, von Tresckow, Bastian, additional, and Borchmann, Sven, additional

Published
2023
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5. P008: Impact of bone marrow involvement on early PET response and progression-free survival in the HD18 trial for patients with advanced-stage Hodgkin lymphoma

Author

Voltin, Conrad-Amadeus, primary, Kreissl, Stefanie, additional, Kaul, Helen, additional, Bühnen, Ina, additional, Mettler, Jasmin, additional, Pabst, Thomas, additional, Eichenauer, Dennis A., additional, Fuchs, Michael, additional, Diehl, Volker, additional, Dietlein, Markus, additional, Engert, Andreas, additional, Borchmann, Peter, additional, and Kobe, Carsten, additional

Published
2022
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7. P024: Predictive Value of Baseline Metabolic Tumor Volume in Early-Stage Favorable Hodgkin Lymphoma – Data from the Prospective, Multicenter Phase III HD16 Trial

Author

Van Heek, Lutz, primary, Stuka, Colin, additional, Kaul, Helen, additional, Müller, Horst, additional, Mettler, Jasmin, additional, Hitz, Felicitas, additional, Baues, Christian, additional, Fuchs, Michael, additional, Borchmann, Peter, additional, Engert, Andreas, additional, Dietlein, Markus, additional, Voltin, Conrad-Amadeus, additional, and Kobe, Carsten, additional

Published
2022
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8. P037: High breadth whole exome sequencing of circulating tumor DNA identifies novel recurrent genetic alterations in Hodgkin lymphoma

Author

Mammadova, Laman, primary, Heger, Jan-Michel, additional, Mattlener, Julia, additional, Sobesky, Sophia, additional, Cirillo, Melita, additional, Bröckelmann, Paul J., additional, Altmüller, Janine, additional, Kirst, Elisabeth, additional, Kreissl, Stefanie, additional, Lohmann, Mia, additional, Nürnberg, Peter, additional, Engert, Andreas, additional, Borchmann, Peter, additional, Von Tresckow, Bastian, additional, and Borchmann, Sven, additional

Published
2022
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9. T020: Interim PET-guided treatment of early-stage nodular lymphocyte-predominant Hodgkin lymphoma: a subgroup analysis of the GHSG HD16 and HD17 studies

Author

Eichenauer, Dennis A., primary, Bühnen, Ina, additional, Fuchs, Michael, additional, Greil, Richard, additional, Moccia, Alden, additional, Zijlstra, Josée. M., additional, Hartmann, Sylvia, additional, Kobe, Carsten, additional, Dietlein, Markus, additional, Engert, Andreas, additional, and Borchmann, Peter, additional

Published
2022
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10. P097: The status quo of involved-field radiotherapy – Quality analysis of radiotherapy in the GHSG HD 16

Author

Oertel, Michael, primary, Hering, Dominik, additional, Kittel, Christopher, additional, Nacke, Nina, additional, Kröger, Kai, additional, Kriz, Jan, additional, Fuchs, Michael, additional, Baues, Christian, additional, Vordermark, Dirk, additional, Engenhart-Cabillic, Rita, additional, Herfarth, Klaus, additional, Lukas, Peter, additional, Schmidberger, Heinz, additional, Marnitz, Simone, additional, Borchmann, Peter, additional, Haverkamp, Uwe, additional, Engert, Andreas, additional, and Eich, Hans Theodor, additional

Published
2022
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11. T002: Treatment related morbidity in patients with classical Hodgkin Lymphoma: results of the ongoing, randomized phase III HD21 Trial by The German Hodgkin Study Group

Author

Borchmann, Peter, primary, Moccia, Alden, additional, Greil, Richard, additional, Herzberg, Mark, additional, Fosså, Alexander, additional, Hüttmann, Andreas, additional, Keil, Felix, additional, Dierlamm, Judith, additional, Schaub, Valdete, additional, Hänel, Mathias, additional, Novak, Urban, additional, Meissner, Julia, additional, Hellmuth, Johannes, additional, Mathas, Stephan, additional, Zijlstra, Josée. M., additional, Viardot, Andreas, additional, Hertenstein, Bernd, additional, Martin, Sonja, additional, Giri, Pratush, additional, Kreissl, Stefanie, additional, Fuchs, Michael, additional, Schneider, Gundolf, additional, Rosenwald, Andreas, additional, Klapper, Wolfram, additional, Eich, Hans Theodor, additional, Baues, Christian, additional, Hallek, Michael, additional, Kobe, Carsten, additional, Diehl, Volker, additional, and Engert, Andreas, additional

Published
2022
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13. P092: Estimating the dosimetric benefit of involved-node radiotherapy in comparison to involved-field radiotherapy - implications from the GHSG HD 17 trial

Author

Oertel, Michael, primary, Hering, Dominik, additional, Nacke, Nina, additional, Kittel, Christopher, additional, Kröger, Kai, additional, Kriz, Jan, additional, Fuchs, Michael, additional, Baues, Christian, additional, Vordermark, Dirk, additional, Engenhart-Cabillic, Rita, additional, Herfarth, Klaus, additional, Lukas, Peter, additional, Schmidberger, Heinz, additional, Marnitz, Simone, additional, Borchmann, Peter, additional, Engert, Andreas, additional, Haverkamp, Uwe, additional, and Eich, Hans Theodor, additional

Published
2022
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14. P093: From involved- field to involved-node – Quality analysis of the radiation therapy in HD 17 by the expert panel of the German Hodgkin Study Group

Author

Oertel, Michael, primary, Hering, Dominik, additional, Nacke, Nina, additional, Kittel, Christopher, additional, Kröger, Kai, additional, Kriz, Jan, additional, Fuchs, Michael, additional, Baues, Christian, additional, Vordermark, Dirk, additional, Engenhart-Cabillic, Rita, additional, Herfarth, Klaus, additional, Lukas, Peter, additional, Schmidberger, Heinz, additional, Marnitz, Simone, additional, Borchmann, Peter, additional, Engert, Andreas, additional, Haverkamp, Uwe, additional, and Eich, Hans Theodor, additional

Published
2022
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22. Reduced-Intensity Chemotherapy in Patients With Advanced-Stage Hodgkin Lymphoma

Author

Engert, Andreas, Goergen, Helen, Markova, Jana, Pabst, Thomas, Meissner, Julia, Zijlstra, Josée M., Král, Zdenek, Eichenauer, Dennis A., Soekler, Martin, Greil, Richard, Kreissl, Stefanie, Scheuvens, Ruth, Eich, Hans, Kobe, Carsten, Dietlein, Markus, Stein, Harald, Fuchs, Michael, Diehl, Volker, and Borchmann, Peter

Subjects
long-term outcome, lcsh:RC633-647.5, Original Article, Advanced stages, lcsh:Diseases of the blood and blood-forming organs, Hodgkin lymphoma
Abstract

The international, randomized phase 3 HD15 trial established 6xeBEACOPP as standard therapy for patients with newly diagnosed advanced-stage Hodgkin lymphoma (HL) within the German Hodgkin Study Group (GHSG). We performed a follow-up analysis to assess long-term efficacy and safety of this approach. Between 2003 and 2008, 2182 patients aged 18 to 60 years were recruited and randomized in a 1:1:1 ratio between 8 or 6 cycles of eBEACOPP or 8 cycles of the dose-dense BEACOPP-14 regimen, each followed by 30 Gy radiotherapy in case of positron emission tomography (PET)-positive residual lesions ≥2.5 cm. The study aimed at demonstrating non-inferiority regarding efficacy of the 2 experimental arms on a significance level of 2.5% each. The intention-to-treat analysis comprised 2126 patients with a median follow-up of 102 months. Ten-year progression-free survival was 81% (97.5% CI 77–85) with 8xeBEACOPP, 84% (80–87) with 6xeBEACOPP, and 84% (80–87) with 8xBEACOPP-14; the non-inferiority margin of 1.51 for the hazard ratio (HR) could be excluded for both comparisons (6xeBEACOPP, HR = 0.7, 97.5% CI 0.5–1.0; 8xBEACOPP-14, HR = 0.9, 97.5% CI 0.7–1.2). Overall survival at 10 years was 88% (85–91), 90% (88–93), and 92% (89–94), respectively. A total of 142 second malignancies corresponding to 10-year cumulative incidences of 10%, 7%, and 7% and standardized incidence ratios of 4.3, 2.5, and 2.8 were reported for 8xeBEACOPP, 6xeBEACOPP, and 8xBEACOPP-14, respectively. This updated analysis of the HD15 trial thus confirms the efficacy and reports on the long-term safety of a shortened first-line chemotherapy consisting of 6xeBEACOPP followed by PET-guided radiotherapy in advanced-stage HL.

Published
2017

26. HemaSphere

Author

Engert, Andreas, primary, Belliard, Frédérique, additional, Sonneveld, Pieter, additional, and Cools, Jan, additional

Published
2018
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