1. Spleen magnetic resonance diffusion-weighted imaging for quantitative staging hepatic fibrosis in miniature pigs: An initial study.
- Author
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Chen, Xiao‐li, Chen, Tian‐wu, Zhang, Xiao‐ming, Li, Zhen‐lin, Li, Hang, Zeng, Nan‐lin, Tang, Hong‐jie, Pu, Yu, Chen, Nan, Yang, Qi, Li, Li, Xie, Xian‐yong, and Hu, Jiani
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HEPATIC fibrosis , *DIFFUSION magnetic resonance imaging , *LABORATORY swine , *SPLEEN , *DISEASE progression , *PARAMETER estimation , *LIVER radiography - Abstract
Aim To determine whether spleen diffusion-weighted imaging ( DWI) parameters might classify liver fibrosis stage. Methods Sixteen miniature pigs were prospectively used to model liver fibrosis, and underwent spleen DWI by using b = 300, 500 and 800 s/mm2 on 0, 5th, 9th, 16th and 21st weekend after the beginning of modeling. Signal intensity ratio of spleen to paraspinous muscles ( S/ M), spleen exponential apparent diffusion coefficient (e ADC) and apparent diffusion coefficient ( ADC) for each b-value were statistically analyzed. Results With increasing stages of fibrosis, S/ M for all b-values showed a downward trend; and spleen e ADC and ADC for b = 300 s/mm2 showed downward and upward trends, respectively (all P < 0.05). The area under the receiver-operator curve ( AUC) of spleen DWI parameters was 0.777 or more by S/ M for classifying each fibrosis stage, and 0.65 or more by e ADC and 0.648 or more by ADC for classifying stage ≥3 or cirrhosis. Among the spleen DWI parameters, S/ M for b = 300 s/mm2 was the best parameter in classifying stage 1 or more, 2 or more and 3 or more with AUC of 0.875, 0.851 and 0.843, respectively; and spleen eADC for b = 300 s/mm2 was best in classifying stage 4 with an AUC of 0.988. Conclusion Spleen DWI may be used to stage liver fibrosis. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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