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Your search keyword '"Kan, Hiromi"' showing total 17 results
Start Over Author "Kan, Hiromi" Journal hepatology research
17 results on '"Kan, Hiromi"'

3. Efficacy and safety of the anticoagulant drug, danaparoid sodium, in the treatment of portal vein thrombosis in patients with liver cirrhosis

Author

Naeshiro, Noriaki, Aikata, Hiroshi, Hyogo, Hideyuki, Kan, Hiromi, Fujino, Hatsue, Kobayashi, Tomoki, Fukuhara, Takayuki, Honda, Yohji, Nakahara, Takashi, Ohno, Atsushi, Miyaki, Daisuke, Murakami, Eisuke, Kawaoka, Tomokazu, Tsuge, Masataka, Hiraga, Nobuhiko, Hiramatsu, Akira, Imamura, Michio, Kawakami, Yoshiiku, Ochi, Hidenori, and Chayama, Kazuaki

Published
2015
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4. Role of 3-D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

Author

Fujino, Hatsue, Kimura, Tomoki, Aikata, Hiroshi, Miyaki, Daisuke, Kawaoka, Tomokazu, Kan, Hiromi, Fukuhara, Takayuki, Kobayashi, Tomoki, Naeshiro, Noriaki, Honda, Yohji, Tsuge, Masataka, Hiramatsu, Akira, Imamura, Michio, Kawakami, Yoshiiku, Hyogo, Hideyuki, Takahashi, Shoichi, Yoshimatsu, Rika, Yamagami, Takuji, Kenjo, Masahiro, Nagata, Yasushi, Awai, Kazuo, and Chayama, Kazuaki

Published
2015
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7. Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C

Author

Nagaoki, Yuko, Imamura, Michio, Kawakami, Yoshiiku, Kan, Hiromi, Fujino, Hatsue, Fukuhara, Takayuki, Kobayashi, Tomoki, Ono, Atsushi, Nakahara, Takashi, Naeshiro, Noriaki, Urabe, Ayako, Yokoyama, Satoe, Miyaki, Daisuke, Murakami, Eisuke, Kawaoka, Tomokazu, Tsuge, Masataka, Hiramatsu, Akira, Aikata, Hiroshi, Takahashi, Shoichi, Hayes, Nelson C., Ochi, Hidenori, and Chayama, Kazuaki

Published
2014
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10. Improvement of renal dysfunction in a patient with hepatitis C virus-related liver cirrhosis by daclatasvir and asunaprevir combination therapy: A case report

Author

Tsuge, Masataka, primary, Hiramatsu, Akira, additional, Shinohara, Fumi, additional, Nakano, Norihito, additional, Nakamura, Yuki, additional, Hatooka, Masahiro, additional, Morio, Kei, additional, Morio, Reona, additional, Kan, Hiromi, additional, Fujino, Hatsue, additional, Uchida, Takuro, additional, Kobayashi, Tomoki, additional, Fukuhara, Takayuki, additional, Masaki, Keiichi, additional, Nakahara, Takashi, additional, Ono, Atsushi, additional, Nagaoki, Yuko, additional, Miki, Daiki, additional, Kawaoka, Tomokazu, additional, Hiraga, Nobuhiko, additional, Imamura, Michio, additional, Kawakami, Yoshiiku, additional, Aikata, Hiroshi, additional, Ochi, Hidenori, additional, Nelson Hayes, C., additional, and Chayama, Kazuaki, additional

Published
2016
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11. Influence of the rs738409 polymorphism in patatin-like phospholipase 3 on the treatment efficacy of non-alcoholic fatty liver disease with type 2 diabetes mellitus

Author

Kan, Hiromi, primary, Hyogo, Hideyuki, additional, Ochi, Hidenori, additional, Hotta, Kikuko, additional, Fukuhara, Takayuki, additional, Kobayashi, Tomoki, additional, Naeshiro, Noriaki, additional, Honda, Yohji, additional, Kawaoka, Tomokazu, additional, Tsuge, Masataka, additional, Hiramatsu, Akira, additional, Imamura, Michio, additional, Kawakami, Yoshiiku, additional, Aikata, Hiroshi, additional, and Chayama, Kazuaki, additional

Published
2015
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12. Effects of ITPA polymorphism on decrease of hemoglobin during simeprevir, peg-interferon, and ribavirin combination treatment for chronic hepatitis C.

Author

Morio, Kei, Imamura, Michio, Kawakami, Yoshiiku, Morio, Reona, Hatooka, Masahiro, Kan, Hiromi, Fujino, Hatsue, Fukuhara, Takayuki, Kobayashi, Tomoki, Masaki, Keiichi, Ono, Atsushi, Nakahara, Takashi, Urabe, Ayako, Yokoyama, Satoe, Nagaoki, Yuko, Kawaoka, Tomokazu, Hiraga, Nobuhiko, Tsuge, Masataka, Hiramatsu, Akira, and Hayes, C Nelson

Subjects
RIBAVIRIN, HEPATITIS C treatment, GENETIC polymorphisms, HEMOGLOBINS, GENOTYPES
Abstract

Aim Polymorphisms in the ITPA gene influence anemia during peg-interferon (PEG-IFN) and ribavirin (RBV) therapy, but their effects during triple therapy with simeprevir, PEG-IFN, and RBV are not sufficiently known. Methods We analyzed 212 patients with genotype 1 chronic hepatitis C, who were treated with simeprevir plus PEG-IFN/RBV triple therapy, and assessed the effect of the ITPA polymorphism on hemoglobin levels and RBV dose reduction. ITPA (rs1127354) and IFNL4 (ss469415590) polymorphisms were genotyped using the Invader assay. A stepwise multivariate regression analysis was carried out to identify factors associated with outcome of the therapy. Results Reduction of hemoglobin levels was similar between patients treated with simeprevir plus PEG-IFN/RBV and those treated with PEG-IFN/RBV therapy. In simeprevir plus PEG-IFN/RBV-treated patients, decreases in hemoglobin levels were faster and greater, and the cumulative proportion of patients with ribavirin dose reduction was significantly greater in ITPA genotype CC patients than in CA/AA patients. The total dose of simeprevir and PEG-IFN was similar between ITPA genotype CC and CA/AA patients. In contrast, the total dose of RBV was lower in patients with the CC genotype. Multivariate analysis showed that the IFNL4 TT/TT genotype, but not the ITPA SNP genotype, treatment history (treatment-naive or relapse during prior treatment), and treatment completion were significantly associated with outcome of therapy. Conclusion ITPA polymorphism influences hemoglobin levels and incidence of RVB dose reduction during simeprevir triple therapy, indicating the importance of monitoring anemia during treatment, particularly for ITPA genotype CC patients. [ABSTRACT FROM AUTHOR]

Published
2016
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13. Disseminated carcinomatosis of the bone marrow originating from hepatocellular carcinoma. A case report

Author

Honda, Yohji, primary, Kawaoka, Tomokazu, additional, Aikata, Hiroshi, additional, Kan, Hiromi, additional, Fujino, Hatsue, additional, Kobayashi, Tomoki, additional, Fukuhara, Takayuki, additional, Naeshiro, Noriaki, additional, Hiramatsu, Akira, additional, Imamura, Michio, additional, Kawakami, Yoshiiki, additional, Hyogo, Hideyuki, additional, Arihiro, Koji, additional, and Chayama, Kazuaki, additional

Published
2014
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14. Efficacy and safety of the anticoagulant drug, danaparoid sodium, in the treatment of portal vein thrombosis in patients with liver cirrhosis

Author

Naeshiro, Noriaki, primary, Aikata, Hiroshi, additional, Hyogo, Hideyuki, additional, Kan, Hiromi, additional, Fujino, Hatsue, additional, Kobayashi, Tomoki, additional, Fukuhara, Takayuki, additional, Honda, Yohji, additional, Nakahara, Takashi, additional, Ohno, Atsushi, additional, Miyaki, Daisuke, additional, Murakami, Eisuke, additional, Kawaoka, Tomokazu, additional, Tsuge, Masataka, additional, Hiraga, Nobuhiko, additional, Hiramatsu, Akira, additional, Imamura, Michio, additional, Kawakami, Yoshiiku, additional, Ochi, Hidenori, additional, and Chayama, Kazuaki, additional

Published
2014
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15. Role of 3‐D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

Author

Fujino, Hatsue, primary, Kimura, Tomoki, additional, Aikata, Hiroshi, additional, Miyaki, Daisuke, additional, Kawaoka, Tomokazu, additional, Kan, Hiromi, additional, Fukuhara, Takayuki, additional, Kobayashi, Tomoki, additional, Naeshiro, Noriaki, additional, Honda, Yohji, additional, Tsuge, Masataka, additional, Hiramatsu, Akira, additional, Imamura, Michio, additional, Kawakami, Yoshiiku, additional, Hyogo, Hideyuki, additional, Takahashi, Shoichi, additional, Yoshimatsu, Rika, additional, Yamagami, Takuji, additional, Kenjo, Masahiro, additional, Nagata, Yasushi, additional, Awai, Kazuo, additional, and Chayama, Kazuaki, additional

Published
2014
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17. Percutaneous transvenous embolization for portosystemic shunts associated with encephalopathy: Long-term outcomes in 14 patients

Author

Naeshiro, Noriaki, primary, Kakizawa, Hideaki, additional, Aikata, Hiroshi, additional, Kan, Hiromi, additional, Fujino, Hatsue, additional, Fukuhara, Takayuki, additional, Kobayashi, Tomoki, additional, Honda, Yohji, additional, Miyaki, Daisuke, additional, Kawaoka, Tomokazu, additional, Tsuge, Masataka, additional, Hiramatsu, Akira, additional, Imamura, Michio, additional, Kawakami, Yoshiiku, additional, Hyogo, Hideyuki, additional, Ishikawa, Masaki, additional, Awai, Kazuo, additional, and Chayama, Kazuaki, additional

Published
2013
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