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32 results on '"Sakisaka, Shotaro"'

1. Frequency of null genotypes of glutathione S‐transferase M1 and T1 in Japanese patients with drug‐induced liver injury

Author

Maeda, Kazuya, primary, Takikawa, Hajime, additional, Aiso, Mitsuhiko, additional, Tsuji, Kenji, additional, Kagawa, Tatehiro, additional, Watanabe, Masaaki, additional, Sato, Ken, additional, Sakisaka, Shotaro, additional, Hiasa, Yoichi, additional, Takei, Yoshiyuki, additional, Ohira, Hiromasa, additional, Hashimoto, Etsuko, additional, Ayada, Minoru, additional, Ikegami, Tadashi, additional, Arakawa, Noriaki, additional, Kusuhara, Hiroyuki, additional, Saito, Yoshiro, additional, and Sugiyama, Yuichi, additional

Published
2022
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5. Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis

Author

Nakamura, Minoru, Kondo, Hisayoshi, Tanaka, Atsushi, Komori, Atsumasa, Ito, Masahiro, Yamamoto, Kazuhide, Ohira, Hiromasa, Zeniya, Mikio, Hashimoto, Etsuko, Honda, Masao, Kaneko, Shuichi, Ueno, Yoshiyuki, Kikuchi, Kentaro, Shimoda, Shinji, Harada, Kenichi, Arai, Kuniaki, Miyake, Yasuhiro, Abe, Masanori, Taniai, Makiko, Saibara, Toshiji, Sakisaka, Shotaro, Takikawa, Hajime, Onji, Morikazu, Tsubouchi, Hirohito, Nakanuma, Yasuni, and Ishibashi, Hiromi

Published
2015
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9. Late-evening snack with branched-chain amino acids improves liver function after radiofrequency ablation for hepatocellular carcinoma

Author

Morihara, Daisuke, Iwata, Kaoru, Hanano, Takayuki, Kunimoto, Hideo, Kuno, Shizuka, Fukunaga, Atsushi, Yotsumoto, Kaoru, Takata, Kazuhide, Tanaka, Takashi, Sakurai, Kunitoshi, Iwashita, Hideyuki, Ueda, Shu-ichi, Hirano, Genryu, Yokoyama, Keiji, Nakane, Hidetoshi, Nishizawa, Shinya, Yoshikane, Makoto, Anan, Akira, Takeyama, Yasuaki, Kakumitsu, Shigeru, Kitamura, Yuji, Sakamoto, Masaharu, Irie, Makoto, Shakado, Satoshi, Sohda, Tetsuro, Watanabe, Hiroshi, and Sakisaka, Shotaro

Published
2012
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13. Clinical features of Wilson disease: Analysis of 10 cases

Author

Takeyama, Yasuaki, Yokoyama, Keiji, Takata, Kazuhide, Tanaka, Takashi, Sakurai, Kunitoshi, Matsumoto, Teruo, Iwashita, Hideyuki, Ueda, Shu-ichi, Hirano, Genryu, Hanano, Takayuki, Nakane, Hidetoshi, Morihara, Daisuke, Nishizawa, Shinya, Yoshikane, Makoto, Anan, Akira, Kakumitsu, Shigeru, Kitamura, Yuji, Sakamoto, Masaharu, Irie, Makoto, Iwata, Kaoru, Shakado, Satoshi, Sohda, Tetsuro, Watanabe, Hiroshi, Hirose, Shinichi, Hayashi, Hideyuki, Noritomi, Tomoaki, Yamashita, Yuichi, and Sakisaka, Shotaro

Published
2010
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20. Analysis of 307 cases with drug‐induced liver injury between 2010 and 2018 in Japan

Author

Aiso, Mitsuhiko, primary, Takikawa, Hajime, additional, Tsuji, Keiji, additional, Kagawa, Tatehiro, additional, Watanabe, Masaaki, additional, Tanaka, Atsushi, additional, Sato, Ken, additional, Sakisaka, Shotaro, additional, Hiasa, Yoichi, additional, Takei, Yoshiyuki, additional, Ohira, Hiromasa, additional, Ayada, Minoru, additional, Hashimoto, Etsuko, additional, Kaneko, Shuichi, additional, Ueno, Yoshiyuki, additional, Ohmoto, Kenji, additional, Takaki, Akinobu, additional, Torimura, Takuji, additional, Matsuzaki, Yasushi, additional, Tajiri, Kazuto, additional, Yoneda, Masashi, additional, Ito, Takayoshi, additional, Kato, Naoya, additional, Ikejima, Kenichi, additional, Mochida, Satoshi, additional, Yasuda, Hiroshi, additional, and Sakamoto, Naoya, additional

Published
2019
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25. Non‐response to daclatasvir and asunaprevir therapy in patients co‐infected with hepatitis C virus genotypes 1 and 2

Author

Sohda, Tetsuro, primary, Yamauchi, Eri, additional, Anan, Akira, additional, Yokoyama, Keiji, additional, Fukunaga, Atsushi, additional, Yamauchi, Ryo, additional, Fukuda, Sho, additional, Takata, Kazuhide, additional, Tanaka, Takashi, additional, Hanano, Takayuki, additional, Kitamura, Yuji, additional, Morihara, Daisuke, additional, Takeyama, Yasuaki, additional, Irie, Makoto, additional, Shakado, Satoshi, additional, and Sakisaka, Shotaro, additional

Published
2016
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26. Long-term follow up of peginterferon-α-2a treatment of hepatitis B e-antigen (HBeAg) positive and HBeAg negative chronic hepatitis B patients in phase II and III studies

Author

Okanoue, Takeshi, primary, Shima, Toshihide, additional, Hasebe, Chitomi, additional, Karino, Yoshiyasu, additional, Imazeki, Fumio, additional, Kumada, Takashi, additional, Minami, Masahito, additional, Imai, Yasuharu, additional, Yoshihara, Harumasa, additional, Mita, Eiji, additional, Morikawa, Teruhisa, additional, Nishiguchi, Shuhei, additional, Kawakami, Yoshiiku, additional, Nomura, Hideyuki, additional, Sakisaka, Shotaro, additional, Kurosaki, Masayuki, additional, Yatsuhashi, Hiroshi, additional, Oketani, Makoto, additional, Kohno, Hiroshi, additional, Masumoto, Akihide, additional, Ikeda, Kenji, additional, and Kumada, Hiromitsu, additional

Published
2016
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27. Non-response to daclatasvir and asunaprevir therapy in patients co-infected with hepatitis C virus genotypes 1 and 2.

Author

Sohda, Tetsuro, Yamauchi, Eri, Anan, Akira, Yokoyama, Keiji, Fukunaga, Atsushi, Yamauchi, Ryo, Fukuda, Sho, Takata, Kazuhide, Tanaka, Takashi, Hanano, Takayuki, Kitamura, Yuji, Morihara, Daisuke, Takeyama, Yasuaki, Irie, Makoto, Shakado, Satoshi, and Sakisaka, Shotaro

Subjects
IMIDAZOLES, SULFONAMIDE drugs, HEPATITIS C treatment, MIXED infections, COMBINATION drug therapy, THERAPEUTICS
Abstract

Direct-acting antiviral agents for hepatitis C virus (HCV) have been developed such as combined daclatasvir (DCV) and asunaprevir (ASV) treatment. This typically enables HCV serotype 1 patients to achieve a high sustained virological response rate, but a small number of such patients fail to respond to therapy. We investigated three HCV patients who showed no response to DCV and ASV therapy. Hepatitis C genotyping was undertaken in the three patients using nested polymerase chain reaction and polymerase chain reaction direct sequencing in the core region of the HCV genome. All three patients possessed HCV serotype 1, and no mutations were identified in either the non-structural protein 3 or 5A region. The three patients were shown to be co-infected with HCV genotypes 1 and 2 because genotypes 2a and 2b were also identified. This is the first report into failed response to DCV and ASV therapy in patients co-infected with HCV genotypes 1 and 2. [ABSTRACT FROM AUTHOR]

Published
2017
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28. Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis

Author

Nakamura, Minoru, primary, Kondo, Hisayoshi, additional, Tanaka, Atsushi, additional, Komori, Atsumasa, additional, Ito, Masahiro, additional, Yamamoto, Kazuhide, additional, Ohira, Hiromasa, additional, Zeniya, Mikio, additional, Hashimoto, Etsuko, additional, Honda, Masao, additional, Kaneko, Shuichi, additional, Ueno, Yoshiyuki, additional, Kikuchi, Kentaro, additional, Shimoda, Shinji, additional, Harada, Kenichi, additional, Arai, Kuniaki, additional, Miyake, Yasuhiro, additional, Abe, Masanori, additional, Taniai, Makiko, additional, Saibara, Toshiji, additional, Sakisaka, Shotaro, additional, Takikawa, Hajime, additional, Onji, Morikazu, additional, Tsubouchi, Hirohito, additional, Nakanuma, Yasuni, additional, and Ishibashi, Hiromi, additional

Published
2014
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29. Liver transplantation in Japan: Registry by the Japanese Liver Transplantation Society.

Author

Umeshita, Koji, Inomata, Yukihiro, Furukawa, Hiroyuki, Kasahara, Mureo, Kawasaki, Seiji, Kobayashi, Eiji, Kokudo, Norihiro, Sakisaka, Shotaro, Shimada, Mitsuo, Tanaka, Eiji, and Uemoto, Shinji

Subjects
LIVER transplantation, MEDICAL registries, PUBLIC health, MEDICAL societies, ORGAN donors
Abstract

As of December 31, 2013, a total of 7474 liver transplants have been carried out at 66 institutions in Japan. This total included 7255 living-donor transplants and 219 deceased-donor transplants (216 from heart-beating donors and 3 from non-heart-beating donors). The annual total of liver transplants in 2013 decreased to 408, from 422 in 2012. The number of liver transplants from living donors decreased to 369, from 381, whereas the number of liver transplants from heart-beating deceased donors did not change significantly. The most frequent indication was cholestatic disease, followed by neoplastic disease. In terms of graft liver in living-donor cases, right-lobe graft was the most popular (36%). Patient survival following transplantations from heart-beating donors (1 year, 85.9%; 3 years, 82.6%; 5 years, 81.3%; 10 years, 73.8%) was similar to those from living donors (1 year, 83.8%; 3 years, 79.6%; 5 years, 77.1%; 10 years, 71.9%; 15 years, 67.8%; 20 years, 66.1%). Graft survival was very much the same as patient survival. As for ABO-incompatible transplantation, transplant period affected the outcome significantly, probably due to local infusion therapy and rituximab prophylaxis, which were introduced in many transplant centers after 2000 and 2004, respectively. [ABSTRACT FROM AUTHOR]

Published
2016
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31. Interleukin 28 B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan.

Author

Shakado, Satoshi, Sakisaka, Shotaro, Okanoue, Takeshi, Chayama, Kazuaki, Izumi, Namiki, Toyoda, Joji, Tanaka, Eiji, Ido, Akio, Takehara, Tetsuo, Yoshioka, Kentaro, Hiasa, Yoichi, Nomura, Hideyuki, Seike, Masataka, Ueno, Yoshiyuki, and Kumada, Hiromitsu

Subjects
*INTERLEUKINS, *SINGLE nucleotide polymorphisms, *RIBAVIRIN, *HEALTH outcome assessment, *HEPATITIS C virus, *PUBLIC health
Abstract

Aim This study evaluated the efficacy of interferon plus ribavirin and examined whether interleukin 28B ( IL28B) polymorphism influenced treatment outcome in Japanese patients with hepatitis C virus ( HCV)-related liver cirrhosis ( LC). Methods Fourteen collaborating centers provided details of 261 patients with HCV-related LC undergoing treatment with interferon plus ribavirin. Univariate and multivariate analyses were used to establish which factors predicted treatment outcome. Results Eighty-four patients (32.2%) achieved a sustained virological response ( SVR). SVR rates were 21.6% (41/190) in patients with HCV genotype 1 with high viral load ( G1H) and 60.6% (43/71) in patients with non- G1H. In patients with non- G1H, treatment outcome was effective irrespective of IL28B polymorphism. In those with G1H, SVR was achieved in 27.1% of patients with the IL28B rs8099917 TT allele compared with 8.8% of those with the TG/ GG alleles ( P = 0.004). In patients with G1H having TT allele, treatments longer than 48 weeks achieved significantly higher SVR rates than treatments less than 48 weeks (34.6% vs 16.4%, P = 0.042). In patients with G1H having TG/ GG alleles, treatments longer than 72 weeks achieved significantly higher SVR rates than treatments less than 72 weeks (37.5% vs 4.1%, P = 0.010). Conclusion Interferon plus ribavirin treatment in Japanese patients with non- G1H HCV-related LC was more effective than those with G1H and not influenced by IL28B polymorphism. In those with G1H, IL28B polymorphism may predict SVR and guide treatment duration: SVR rates were higher in those with the TT allele treated for more than 48 weeks and those with the TG/ GG alleles treated for more than 72 weeks. [ABSTRACT FROM AUTHOR]

Published
2014
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32. Bronchiolitis obliterans organizing pneumonia in a patient with primary biliary cirrhosis and rheumatoid arthritis treated with prednisolone

Author

Harada, Masaru, Hashimoto, Osamu, Kumemura, Hiroto, Taniguchi, Eitaro, Shiratsuchi, Mutsuhito, Harada, Riko, Sakamoto, Masaharu, Yoshida, Hiroshi, Fukuda, Takaaki, Sakisaka, Shotaro, and Sata, Michio

Subjects
RHEUMATOID arthritis, BRONCHITIS, PNEUMONIA, ANTI-inflammatory agents
Abstract

A 62-year-old woman with primary biliary cirrhosis (PBC) and rheumatoid arthritis (RA) was examined at our hospital for a 2-week history of non-resolving fever, cough and malaise. Her chest radiograph revealed left lower lobe opacity. Various kinds of antibiotics were not effective and transbronchial biopsy revealed non-specific inflammatory alveolar lesions. Chest radiograph at 14 days after admission revealed migration of the pulmonary opacity, suggesting bronchiolitis obliterans organizing pneumonia (BOOP), which responded well clinically and radiologically to oral corticosteroid therapy. BOOP may be one of the possible non-hepatic complications of PBC especially in patients associated with other connective tissue diseases. [ABSTRACT FROM AUTHOR]

Published
2002
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