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Background Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon. Methods The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn. Results None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for MMP-2, MMP-7 and MT2A non-significant differences in genotypes frequencies among cases and controls were observed. Conclusions Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation. Keywords: Prostate cancer, Matrix metalloproteinases, Metallothioneins, Polymorphisms, Author(s): Katarzyna BiaÅkowska[sup.1], Wojciech Marciniak[sup.2], Magdalena MuszyÅska[sup.2], Piotr Baszuk[sup.1], Satish Gupta[sup.3], Katarzyna Jaworska-Bieniek[sup.1], Grzegorz Sukiennicki[sup.1], Katarzyna Durda[sup.1], Tomasz Gromowski[sup.1], Marcin Lener[sup.1], Karolina Prajzendanc[sup.1], Alicja Åukomska[sup.1], Cezary Cybulski[sup.1], Tomasz Huzarski[sup.1], Jacek [...]

Abstract The study was conducted to determine the correlations between serum concentration of arsenic (As) with increased or decreased predisposition to breast and ovarian cancer.

Author(s): Marcin Lener[sup.1] , Anna Wiechowska-KozÅowska[sup.2] , Magdalena MuszyÅska[sup.3] , Katarzyna Jaworska-Bieniek[sup.1] , Grzegorz Sukiennicki[sup.1] , Katarzyna Kaczmarek[sup.1] , Tomasz Gromowski[sup.1] , Wojciech Marciniak[sup.3] , Anna Jakubowska[sup.1] and Jan LubiÅski[sup.1,3] [...]

Author(s): Katarzyna Kaczmarek[sup.1] , Magdalena MuszyÅska[sup.2] , Katarzyna Jaworska-Bieniek[sup.1] , Wojciech Marciniak[sup.2] , Grzegorz Sukiennicki[sup.1] , Marcin Lener[sup.1] , Katarzyna Durda[sup.1] , Tomasz Gromowski[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] [...]

Author(s): Grzegorz Sukiennicki[sup.1] , Magdalena MuszyÅska[sup.2] , Katarzyna Jaworska-Bieniek[sup.1] , Katarzyna Kaczmarek[sup.1] , Wojciech Marciniak[sup.2] , Marcin Lener[sup.1] , Katarzyna Durda[sup.1] , Tomasz Gromowski[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] [...]

Author(s): Katarzyna Jaworska-Bieniek[sup.1] , Magdalena MuszyÅska[sup.2] , Katarzyna Kaczmarek[sup.1] , Wojciech Marciniak[sup.2] , Grzegorz Sukiennicki[sup.1] , Marcin Lener[sup.1] , Katarzyna Durda[sup.1] , Tomasz Gromowski[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] [...]

Background Over half the cancer deaths in HNPCC families are due to extra-colonic malignancies that include endometrial and ovarian cancers. The benefits of surveillance for gynecological cancers are not yet proven and there is no consensus on the optimal surveillance recommendations for women with MMR mutations. Methods We performed a systematic review of the literature and evaluated gynecological cancer risk in a series of 631 Polish HNPCC families classified into either Lynch Syndrome (LS, MMR mutations detected) or HNPCC (fulfillment of the Amsterdam or modified Amsterdam criteria). Results Published data clearly indicates no benefit for ovarian cancer screening in contrast to risk reducing surgery. We confirmed a significantly increased risk of OC in Polish LS families (OR = 4,6, p < 0.001) and an especially high risk of OC was found for women under 50 years of age: OR = 32,6, p < 0.0001 (95% CI 12,96-81,87). The cumulative OC risk to 50 year of life was calculated to be 10%. Six out of 19 (32%) early-onset patients from LS families died from OC within 2 years of diagnosis. We confirmed a significantly increased risk of EC (OR = 26, 95% CI 11,36-58,8; p < 0,001). The cumulative risk for EC in Polish LS families was calculated to be 67%. Conclusions Due to the increased risk of OC and absence of any benefit from gynecological screening reported in the literature it is recommended that prophylactic oophorectomy for female carriers of MMR mutations after 35 year of age should be considered as a risk reducing option. Annual transvaginal ultrasound supported by CA125 or HE4 marker testing should be performed after prophylactic surgery in these women. Due to the high risk of EC it is reasonable to offer, after the age of 35 years, annual clinical gynecologic examinations with transvaginal ultrasound supported by routine aspiration sampling of the endometrium for women from either LS or HNPCC families. An alternative option, which could be taken into consideration for women preferring surgical prevention, is risk reducing total hysterectomy (with bilateral salpingo-oophorectomy) for carriers after childbearing is complete. Keywords: HNPCC, Lynch syndrome, Ovarian cancer, Endometrial cancer, Adnexectomy, Author(s): Tadeusz DÄbniak[sup.1] , Tomasz Gromowski[sup.1] , Rodney J Scott[sup.2] , Jacek Gronwald[sup.1] , Tomasz Huzarski[sup.1] , Tomasz Byrski[sup.1] , Grzegorz Kurzawski[sup.1] , Dagmara Dymerska[sup.1] , Bohdan Górski[sup.1] , Katarzyna [...]