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Valvular heart disease (VHD) is common in patients with impaired renal function, especially in those with end-stage renal disease (ESRD) undergoing dialysis. Progressive sclerosis and calcification of the valves and valvular annuli are major components of the etiology. These processes typically affect the aortic and mitral valve and can lead to both valvular insufficiency and stenosis. As recommended by the 2017 ESC/EACTS Guidelines for the management of VHD, surgical treatment remains the standard care for most cases of severe VHD. However, chronic kidney disease (CKD) is associated with increased mortality when compared with patients with preserved renal function. Interventional treatment options have emerged as an effective and safe alternative for patients older than 75 years and/or with increased surgical risk. Consequently, in patients with CKD at increased surgical risk who have suitable anatomical morphology, transcatheter replacement and/or repair should be discussed in the interdisciplinary "heart team."

The duration of dual antiplatelet therapy (DAPT) after percutaneous coronary interventions (PCI) depends on the type of intervention and the clinical situation of the patient. After angioplasty alone (plain old balloon angioplasty, POBA) DAPT is not yet established but does, however, make sense to continue for 4 weeks. The duration of DAPT after placement of bare metal stents (BMS) is 4 weeks, after drug-eluting stents (DES) 6 months, after bioresorbable vascular scaffold (BVS) systems 6-12 months and after drug-coated balloon catheters (DCB) without a new implant 4 weeks.