1. The 5-hydroxytryptamine4 receptor enables differentiation of informational content and encoding in the hippocampus.
- Author
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Twarkowski H, Hagena H, and Manahan-Vaughan D
- Subjects
- Animals, CA1 Region, Hippocampal drug effects, CA3 Region, Hippocampal drug effects, Dentate Gyrus drug effects, Electric Stimulation, Electrodes, Implanted, Excitatory Postsynaptic Potentials drug effects, Excitatory Postsynaptic Potentials physiology, Long-Term Potentiation drug effects, Long-Term Synaptic Depression drug effects, Male, Perforant Pathway drug effects, Perforant Pathway metabolism, Rats, Wistar, Serotonin 5-HT4 Receptor Agonists, Serotonin 5-HT4 Receptor Antagonists, Synapses drug effects, Synapses metabolism, CA1 Region, Hippocampal metabolism, CA3 Region, Hippocampal metabolism, Dentate Gyrus metabolism, Long-Term Potentiation physiology, Long-Term Synaptic Depression physiology, Receptors, Serotonin, 5-HT4 metabolism
- Abstract
Long-term synaptic plasticity, represented by long-term depression (LTD) and long-term potentiation (LTP) comprise cellular processes that enable memory. Neuromodulators such as serotonin regulate hippocampal function, and the 5-HT4 -receptor contributes to processes underlying cognition. It was previously shown that in the CA1-region, 5-HT4 -receptors regulate the frequency-response relationship of synaptic plasticity: patterned afferent stimulation that has no effect on synaptic strength (i.e., a θm-frequency), will result in LTP or LTD, when given in the presence of a 5-HT4 -agonist, or antagonist, respectively. Here, we show that in the dentate gyrus (DG) and CA3 regions of freely behaving rats, pharmacological manipulations of 5-HT4 -receptors do not influence responses generated at θm-frequencies, but activation of 5-HT4 -receptors prevents persistent LTD in mossy fiber (mf)-CA3, or perforant path-DG synapses. Furthermore, the regulation by 5-HT4 -receptors of LTP is subfield-specific: 5-HT4 -receptor-activation prevents mf-CA3-LTP, but does not strongly affect DG-potentiation. These data suggest that 5-HT4 -receptor activation prioritises information encoding by means of LTP in the DG and CA1 regions, and suppresses persistent information storage in mf-CA3 synapses. Thus, 5-HT4 -receptors serve to shape information storage across the hippocampal circuitry and specify the nature of experience-dependent encoding. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc., (© 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.)
- Published
- 2016
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