Search

Your search keyword '"Leoncini, Lorenzo"' showing total 9 results
Start Over Author "Leoncini, Lorenzo" Journal histopathology
9 results on '"Leoncini, Lorenzo"'

2. Cover Image

Author

Granai, Massimo, primary, Lazzi, Stefano, additional, Mancini, Virginia, additional, Akarca, Ayse, additional, Santi, Raffaella, additional, Vergoni, Federica, additional, Sorrentino, Ester, additional, Guazzo, Raffaella, additional, Mundo, Lucia, additional, Cevenini, Gabriele, additional, Tripodo, Claudio, additional, Di Stefano, Gioia, additional, Puccini, Benedetta, additional, Ponzoni, Maurilio, additional, Sabattini, Elena, additional, Agostinelli, Claudio, additional, Bassüllü, Nuray, additional, Tecimer, Tülay, additional, Demiroz, Ahu Senem, additional, Mnango, Leah, additional, Dirnhofer, Stephan, additional, Quintanilla‐Martinez, Leticia, additional, Marafioti, Teresa, additional, Fend, Falko, additional, and Leoncini, Lorenzo, additional

Published
2021
Full Text
View/download PDF

3. Epstein–Barr virus reactivation influences clonal evolution in human herpesvirus‐8‐related lymphoproliferative disorders

Author

Granai, Massimo, primary, Facchetti, Mattia, additional, Mancini, Virginia, additional, Goedhals, Jacqueline, additional, Sherriff, Alicia, additional, Mundo, Lucia, additional, Bellan, Cristiana, additional, Amato, Teresa, additional, Sorrentino, Ester, additional, Ungari, Marco, additional, Raphael, Martine, additional, Leoncini, Lorenzo, additional, Facchetti, Fabio, additional, and Lazzi, Stefano, additional

Published
2021
Full Text
View/download PDF

4. Burkitt lymphoma with a granulomatous reaction: an M1/Th1‐polarised microenvironment is associated with controlled growth and spontaneous regression

Author

Granai, Massimo, primary, Lazzi, Stefano, additional, Mancini, Virginia, additional, Akarca, Ayse, additional, Santi, Raffaella, additional, Vergoni, Federica, additional, Sorrentino, Ester, additional, Guazzo, Raffaella, additional, Mundo, Lucia, additional, Cevenini, Gabriele, additional, Tripodo, Claudio, additional, Di Stefano, Gioia, additional, Puccini, Benedetta, additional, Ponzoni, Maurilio, additional, Sabattini, Elena, additional, Agostinelli, Claudio, additional, Bassüllü, Nuray, additional, Tecimer, Tülay, additional, Demiroz, Ahu Senem, additional, Mnango, Leah, additional, Dirnhofer, Stephan, additional, Quintanilla‐Martinez, Leticia, additional, Marafioti, Teresa, additional, Fend, Falko, additional, and Leoncini, Lorenzo, additional

Published
2021
Full Text
View/download PDF

6. A refined approach to the diagnosis of Burkitt lymphoma in a resource‐poor setting.

Author

Naresh, Kikkeri N, Lazzi, Stefano, Santi, Raffaella, Granai, Massimo, Onyango, Noel, and Leoncini, Lorenzo

Subjects
CANCER diagnosis, IMMUNOGLOBULIN genes, BREAST
Abstract

If such cases have only I MYC i rearrangement, and a typical BL phenotype, such features are compatible with a diagnosis of BL. I Sir i : Burkitt lymphoma (BL) is among the most studied human malignancies. Hence, we designed an algorithm for the diagnosis of BL applicable for these settings.1,2 In 2011, we published an algorithm for the diagnosis of BL that would assist practising pathologists in a setting of limited resources. [Extracted from the article]

Published
2022
Full Text
View/download PDF

8. The cell of origin of Burkitt lymphoma: germinal centre or not germinal centre?

Author

Pier Paolo Piccaluga, Teresa Amato, Maria Raffaella Ambrosio, Cristiana Bellan, Stefano Lazzi, Lorenzo Leoncini, Giuseppe Lo Bello, Ambrosio, Maria R, Lo Bello, Giuseppe, Amato, Teresa, Lazzi, Stefano, Piccaluga, Pier P, Leoncini, Lorenzo, and Bellan, Cristiana

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Histology, Cell of origin, Burkitt lymphoma germinal center, Biology, Article, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, medicine, Humans, B-Lymphocytes, B-Lymphocyte, virus diseases, Germinal center, General Medicine, Germinal Center, medicine.disease, Burkitt Lymphoma, Lymphoma, 030104 developmental biology, 030220 oncology & carcinogenesis, Human
Abstract

We read with interest the ‘Accepted article’ in Histopathology of Park and colleagues1 that reports novel insight into the early histopathogenesis of immunodeficiency‐associated Burkitt lymphoma (BL), suggesting a possible relationship with monocytoid B cell and speculating on the BL cell of origin. In addition, the paper raises the question of the polymicrobial nature of BL, as cytomegalovirus (CMV) was also detected.

Published
2016
Full Text
View/download PDF

9. Burkitt lymphoma with a granulomatous reaction: an M1/Th1-polarised microenvironment is associated with controlled growth and spontaneous regression.

Author

Granai M, Lazzi S, Mancini V, Akarca A, Santi R, Vergoni F, Sorrentino E, Guazzo R, Mundo L, Cevenini G, Tripodo C, Di Stefano G, Puccini B, Ponzoni M, Sabattini E, Agostinelli C, Bassüllü N, Tecimer T, Demiroz AS, Mnango L, Dirnhofer S, Quintanilla-Martinez L, Marafioti T, Fend F, and Leoncini L

Subjects
Adolescent, Aged, Female, Herpesvirus 4, Human, Humans, Male, Middle Aged, Burkitt Lymphoma pathology, Epstein-Barr Virus Infections pathology, Macrophages pathology, Th1 Cells pathology, Tumor Microenvironment
Abstract

Aims: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that, in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four such cases, two of which regressed spontaneously., Methods and Results: All cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. All four cases were Epstein-Barr virus (EBV)-positive with type I latency. Investigation of the TME showed similar features in all four cases. The analysis revealed a proinflammatory response triggered by Th1 lymphocytes and M1 polarised macrophages encircling the neoplastic cells with a peculiar topographic distribution., Conclusions: Our data provide an in-vivo picture of the role that specific immune cell subsets might play during the early phase of BL, which may be capable of maintaining the tumour in a self-limited state or inducing its regression. These novel results may provide insights into new potential therapeutic avenues in EBV-positive BL patients in the era of cellular immunotherapy., (© 2021 The Authors. Histopathology published by John Wiley & Sons Ltd.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results