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Your search keyword '"Receptors, KIR2DL3 genetics"' showing total 4 results
Start Over Descriptor "Receptors, KIR2DL3 genetics" Journal hla
4 results on '"Receptors, KIR2DL3 genetics"'

1. Discovery of the novel KIR2DL3*00111 allele in a Chinese Han individual.

Author

Zhen J, Yang Z, and Deng Z

Subjects
Humans, Alleles, Base Sequence, China, East Asian People, Exons, Sequence Alignment, Sequence Analysis, DNA methods, Receptors, KIR2DL3 genetics
Abstract

The novel KIR2DL3*00111 allele differs from the closest allele KIR2DL3*00101 by a single silent mutation., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2024
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2. The novel KIR2DL3*037 allele, identified by Sanger dideoxy nucleotide sequencing in a Chinese individual.

Author

Yu Q, Yang Z, and Deng Z

Subjects
Humans, Base Sequence, Codon, East Asian People, Exons, Histocompatibility Testing, Sequence Alignment, Alleles, Mutation, Missense, Receptors, KIR2DL3 genetics, Sequence Analysis, DNA methods
Abstract

The novel KIR2DL3*037 allele differs from the closest allele KIR2DL3*00101 by a single missense mutation., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2024
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3. A single nucleotide substitution in exon 5 generated the novel KIR2DL3*00112 allele.

Author

Li Y and Deng Z

Subjects
Humans, Base Sequence, Sequence Analysis, DNA methods, Histocompatibility Testing, Polymorphism, Single Nucleotide, Point Mutation, Sequence Alignment, Alleles, Exons, Receptors, KIR2DL3 genetics
Abstract

The novel KIR2DL3*00112 allele differs from the closest allele KIR2DL3*00101 by a single same sense mutation., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2024
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4. A novel antibody combination to identify KIR2DS2 high natural killer cells in KIR2DL3/L2/S2 heterozygous donors.

Author

Blunt MD, Rettman P, Bastidas-Legarda LY, Fulton R, Capizzuto V, Naiyer MM, Traherne JA, and Khakoo SI

Subjects
Cell Separation, Cells, Cultured, Flow Cytometry, Heterozygote, Humans, Immunologic Surveillance, Lymphocyte Activation, Receptors, KIR immunology, Receptors, KIR metabolism, Receptors, KIR2DL2 genetics, Receptors, KIR2DL2 immunology, Receptors, KIR2DL2 metabolism, Receptors, KIR2DL3 genetics, Receptors, KIR2DL3 immunology, Receptors, KIR2DL3 metabolism, Antibodies metabolism, Immunophenotyping methods, Killer Cells, Natural metabolism, Neoplasms immunology, Receptors, KIR genetics, Virus Diseases immunology
Abstract

The killer cell immunoglobulin-like receptor (KIR) KIR2DS2 induces natural killer (NK) cell activation upon ligation and in genetic studies is associated with protection against certain cancers and viral infections. One of the difficulties in understanding KIR2DS2 has been that ligands have been hard to define. In part, this is because the high sequence homology between KIR2DS2 and KIR2DL3/KIR2DL2 has made it difficult to make antibodies that specifically detect NK cells expressing KIR2DS2. Using transfected NK cell line (NKL) cells and primary human samples, we report the identification of a novel antibody combination which allows identification of NK cells with relatively high expression of KIR2DS2. This separation is sufficient to examine primary human NK cell activation in response to KIR2DS2 specific ligands., (© 2018 The Authors. HLA published by John Wiley & Sons Ltd.)

Published
2019
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