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In the search of novel potent bioactive com-pounds, 18 novel camphoric acid-based acylhydrazone compounds 4a – 4r were designed and synthesized by the condensation reaction of N -amino camphorimide ( 3 ) with substituted benzaldehyde based on camphoric acid as the starting material. The target compounds were character-ized by means of Fourier transform infrared (FTIR), 1 H nuclear magnetic resonance (NMR), 13 C NM R, electrospray ionization-mass spectrometry (ESI-MS), and elemental analysis. The preliminary bioassay showed that the follow-ing camphoric acid-based compounds exhibited excellent antifungal activity with an inhibition ratio of 95% against Physalospora piricola at the concentration of 50 μ g ml -1 : o -bromophenyl acylhydrazone ( 4f ), p -bromophen acyl - ylhydrazone ( 4g ), p -methoxyphenyl acylhydrazone ( 4m ), and p -hydroxyphenyl acylhydrazone ( 4p ). Keywords: achyydrl azone, antifungal activity, camphoric acid, synthesis *Corresponding author: Wen-Gui Duan, School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxue Road, Nanning 530004, P.R. China, e-mail: wgduan@gxu.edu.cn Xian-Li Ma and Fang-Yao Li: SchooofChemistl yandr Chemical Engineering, Guangxi University, Nanning, P.R. China ; and College of Pharmacy, Guilin Medical University, Guilin, P.R. China Jing-Ni Liao, Zhi-duo Lin, Gui-Shan Lin and Bo Cen: Schooof lChemistry and Chemical Engineering, Guangxi University, Nanning, P.R. China Fu-Hou Lei: Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nanning, P.R. China

In search of new bioactive compounds, a series of maleated rosin-based dithiourea compounds were designed and synthesised with rosin as starting material. All the title compounds were characterised by Fourier transform infra-red spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H NMR), and 13C nuclear magnetic resonance spectroscopy (13C NMR). The preliminary bioassay showed that the target compounds exhibited a certain fungicidal activity against Physalospora piricola at a concentration of 50 μg ml-1 and a certain growth herbicidal activity against the root of rape (Brassica campestris L.) at a concentration of 100 μg ml-1.

To search for novel therapeutic compounds with higher activity, a series of novel dehydroabietic acid derivatives bearing 1,3,4-oxadiazole moieties were designed and synthesized. Ten title compounds 5-dehydroabietyl-2-alkyl thio-1,3,4-oxadiazoles were synthesized by the reaction of 5-dehydroabietyl-2-mercapto-1,3,4-oxadiazole with alkyl halide or substituted benzyl halide in ethanolic KOH. All the title compounds were analyzed and characterized by means of IR, UV-vis, EI-MS, 1H-NMR, 13C-NMR, and elemental analysis. The preliminary herbicidal assay showed that almost all of the compounds exhibited an excellent growth inhibition to rape (Brassica campestris) and a certain inhibition to barnyard grass (Echinochloa crusgalli L.) at a concentration of 100 μg ml-1.