Search

Your search keyword '"Rumiko Aoki"' showing total 3 results
Start Over Author "Rumiko Aoki" Journal hormone research
3 results on '"Rumiko Aoki"'

1. Contents, Vol. 36, 1991

Author

M. Zachmann, C. Jung-Hoffmann, Mikihiko Kudo, Jean-Marie Cottet-Emard, Carlos Dieguez, D. Gambarana, R. Rappaport, T. Ohzeki, Kiyohiko Kato, A. D’Alberton, Kenji Ohyama, Jens Christoffersen, Felipe F. Casanueva, M. Cisternino, Rosa Bussi, R. Keret, G. Giorgiani, Makoto Nakazono, Andrea Giustina, Jose I. Vidal, Fernando Cordido, F. Locatelli, A. Valtorta, F. Severi, C. Gübelin-De Campo, A. Silbergeld, M. Bozzola, Aino Torsson, Hajime Watanobe, M. Ballabio, Meta Damkjœr Nielsen, Masanori Ohta, M. Fitzner, Z. Laron, René Mornex, Masatoshi Fujimoto, Merete Jørgensen, M. Nissim, M. Lapidot, D. Bochicchio, Kazuo Takebe, B. Manella, Rumiko Aoki, Grazia Buffoli, M. Wasserman, I. Ashkenazi, Katharina M. Main, Ieuan A. Hughes, G. Faglia, Knud E. Petersen, Yoshiko Nakagomi, R. Orefice, G. Giorda, Remo Pagliari, William B. Wehrenberg, B. Schindel, Jørn Müller, Niels E. Skakkebæk, H. Kuhl, A.G. Harros, Malou Philips, Niels E. Skakkebœk, Liliane Peyrin, A. Moretta, and Toshitsugu Yamori

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
1991
Full Text
View/download PDF

2. In vivo and in vitro studies in a patient with cyclical Cushing's disease showing some responsiveness to bromocriptine

Author

Makoto Nakazono, Kazuo Takebe, Mikihiko Kudo, Hajime Watanobe, and Rumiko Aoki

Subjects
Adult, endocrine system, medicine.medical_specialty, Periodicity, Pro-Opiomelanocortin, Adenoma, Hydrocortisone, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Pituitary-Adrenal System, In Vitro Techniques, Cushing syndrome, Endocrinology, Anterior pituitary, Adrenocorticotropic Hormone, In vivo, Internal medicine, Medicine, Humans, Cushing Syndrome, Bromocriptine, Transsphenoidal surgery, business.industry, Cushing's disease, medicine.disease, Immunohistochemistry, Circadian Rhythm, medicine.anatomical_structure, Female, Corticotropic cell, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

In vivo and in vitro studies were carried out in a 37-year old female with cyclical Cushing's disease. Preoperative studies revealed periodic secretions of urinary corticosteroids occurring with a cyclicity of 2-3 weeks. On transsphenoidal surgery, a microadenoma was visualized in the anteroinferior portion of the anterior pituitary. Gel filtration analyses of the adenoma and surrounding tissues revealed increased concentrations of beta-endorphin and an activated conversion of beta-lipotropin to beta-endorphin in the adenoma compared with the surrounding tissues. These findings were in agreement with the characteristics previously reported for corticotroph adenomas. However, unexpectedly, concentrations of ACTH and beta-lipotropin in the adenoma were only slightly higher than those in the surrounding tissues. Precise mechanisms underlying this unusual finding were elusive, but it may have been due to the periodic nature of her hypercortisolism. In addition, this patient was reproducibly responsive to bromocriptine (2.5 mg, per os) with a reduction of the plasma cortisol level. Although this may suggest an intermediate lobe subtype of Cushing's disease as proposed by Lamberts' group, our case did not have any other characteristic suggestive of this proposed variant. However, it is tempting to speculate that cyclical changes in the central dopaminergic tone may have been at least a partial trigger for the periodic hormonogenesis in this patient.

Published
1991

3. Subject Index, Vol. 36, 1991

Author

A. Silbergeld, Hajime Watanobe, Masatoshi Fujimoto, M. Lapidot, A. Moretta, Toshitsugu Yamori, Fernando Cordido, Makoto Nakazono, M. Fitzner, F. Locatelli, Knud E. Petersen, Mikihiko Kudo, Jørn Müller, Carlos Dieguez, I. Ashkenazi, D. Gambarana, Yoshiko Nakagomi, R. Rappaport, T. Ohzeki, H. Kuhl, L. Peyrin, Katharina M. Main, C. Jung-Hoffmann, Niels E. Skakkebæk, Meta Damkjœr Nielsen, A. Valtorta, A.G. Harros, Jose I. Vidal, M. Nissim, D. Bochicchio, William B. Wehrenberg, A. D’Alberton, Felipe F. Casanueva, M. Cisternino, G. Giorgiani, Aino Torsson, Rosa Bussi, M. Zachmann, G. Faglia, Malou Philips, R. Orefice, M. Bozzola, G. Giorda, Remo Pagliari, Ieuan A. Hughes, M. Wasserman, Jean-Marie Cottet-Emard, Masanori Ohta, B. Manella, F. Severi, René Mornex, B. Schindel, Rumiko Aoki, Grazia Buffoli, Merete Jørgensen, C. Gübelin-De Campo, Kazuo Takebe, M. Ballabio, Z. Laron, R. Keret, Jens Christoffersen, Andrea Giustina, Kiyohiko Kato, Kenji Ohyama, and Niels E. Skakkebœk

Subjects
Endocrinology, Index (economics), Endocrinology, Diabetes and Metabolism, Statistics, Subject (documents), Mathematics
Published
1991
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results