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Start Over Descriptor "Bone Morphogenetic Protein 1 physiology" Journal hua xi kou qiang yi xue za zhi huaxi kouqiang yixue zazhi west china journal of stomatology

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1 results on '"Bone Morphogenetic Protein 1 physiology"'

1. [Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone].

Author

Xie XD, Zhao L, Wu YF, and Wang J

Subjects
Bone Morphogenetic Protein 1 physiology, Metalloproteases, Tolloid-Like Metalloproteinases, Bone Morphogenetic Proteins, Bone and Bones
Abstract

The bone morphogenetic protein (BMP) 1/tolloid (TLD) proteinase family is a group of important metalloproteinases, which play key roles in the growth and development of tissues and organs via regulating the biosynthetic processing of the extracellular matrix. Clinical reports have revealed that mutations in the genes encoding BMP1/TLD proteinases lead to dentinogenesis imperfecta type Ⅰ, accompanied with osteogenesis imperfecta. Therefore, this proteinase family is essential for the development of hard tissues. In this study, we review the research progress in the function and mechanism of the BMP1/TLD proteinase family in the development of teeth and bone.

Published
2020
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