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Your search keyword '"Teng-Cheong Ha"' showing total 3 results
Start Over Author "Teng-Cheong Ha" Journal human gene therapy
3 results on '"Teng-Cheong Ha"'

1. An Improved Lentiviral Fluorescent Genetic Barcoding Approach Distinguishes Hematopoietic Stem Cell Properties in MultiplexedIn VivoExperiments

Author

Axel Schambach, Anna Lieske, Tobias Maetzig, and Teng Cheong Ha

Subjects
0303 health sciences, education.field_of_study, Population, Hematopoietic stem cell, hemic and immune systems, Computational biology, Biology, DNA barcoding, Regenerative medicine, Viral vector, 03 medical and health sciences, Haematopoiesis, 0302 clinical medicine, medicine.anatomical_structure, In vivo, 030220 oncology & carcinogenesis, Genetics, medicine, Molecular Medicine, Stem cell, education, Molecular Biology, 030304 developmental biology
Abstract

Hematopoietic stem cells (HSC) represent a rare cell population of particular interest for biomedical research and regenerative medicine. Various marker combinations enable the isolation of HSCs bu...

Published
2021

2. Multiple Genes Surrounding Bcl-xL, a Common Retroviral Insertion Site, Can Influence Hematopoiesis Individually or in Concert

Author

Teng-Cheong Ha, Boris Fehse, Olga S. Kustikova, Violetta Dziadek, Maike Stahlhut, Gabi Paul, Martijn H. Brugman, Axel Schambach, Michael Rothe, Christopher Baum, and Michael A. Morgan

Subjects
0303 health sciences, Genetic enhancement, Bcl-xL, Insertion site, Biology, Insertional mutagenesis, 03 medical and health sciences, Haematopoiesis, 0302 clinical medicine, 030220 oncology & carcinogenesis, Genetics, Cancer research, biology.protein, Molecular Medicine, Molecular Biology, Gene, 030304 developmental biology
Abstract

Retroviral insertional mutagenesis (RIM) is both a relevant risk in gene therapy and a powerful tool for identifying genes that enhance the competitiveness of repopulating hematopoietic stem and pr...

Published
2021

3. Multiple Genes Surrounding

Author

Teng-Cheong, Ha, Maike, Stahlhut, Michael, Rothe, Gabi, Paul, Violetta, Dziadek, Michael, Morgan, Martijn, Brugman, Boris, Fehse, Olga, Kustikova, Axel, Schambach, and Christopher, Baum

Subjects
Mice, Retroviridae, Base Sequence, bcl-X Protein, Animals, Humans, Hematopoietic Stem Cells, Hematopoiesis
Abstract

Retroviral insertional mutagenesis (RIM) is both a relevant risk in gene therapy and a powerful tool for identifying genes that enhance the competitiveness of repopulating hematopoietic stem and progenitor cells (HSPCs). However, focusing only on the gene closest to the retroviral vector insertion site (RVIS) may underestimate the effects of RIM, as dysregulation of distal and/or multiple genes by a single insertion event was reported in several studies. As a proof of concept, we examined the common insertion site (CIS)

Published
2020

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