1. A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2–q12.3
- Author
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R. Rangasayee, Rajeev Jalvi, Arunima Chatterjee, Nishtha Pandey, and Anuranjan Anand
- Subjects
Genetic Markers ,Male ,Adolescent ,Hearing loss ,Hearing Loss, Sensorineural ,Locus (genetics) ,Biology ,Hearing Loss, Bilateral ,Genetic linkage ,otorhinolaryngologic diseases ,Genetics ,medicine ,Humans ,Gene ,Genetics (clinical) ,Genes, Dominant ,medicine.diagnostic_test ,Chromosomes, Human, Pair 11 ,Chromosome Mapping ,Chromosome ,Human genetics ,Pedigree ,Genetic marker ,Audiometry, Pure-Tone ,Female ,Lod Score ,medicine.symptom ,Audiometry - Abstract
Autosomal dominant nonsyndromic hearing loss (ADNSHL) accounts for about one-fifth of hereditary hearing loss in humans. In the present study, we have analyzed a three-generation family with 14 of its members manifesting ADNSHL, using a genome-wide linkage mapping approach. We found a novel locus DFNA59 between the D11S929 and D11S480 markers in the chromosome location 11p14.2-q12.3. The highest two-point lod score of 5.72 at recombination fraction = 0 was obtained for D11S4152, D11S4154, D11S1301, D11S905 and D11S1344. The critical genomic region comprising about 37 megabases of DNA is proposed to carry a gene for ADNSHL in the family. About 50 cochlear-expressed genes mapping to the region are strong candidates which we propose to examine to identify the gene responsible for the hearing impairment.
- Published
- 2008
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