1. Association between TNFRSF11B gene polymorphisms and history of ischemic stroke in Italian diabetic patients
- Author
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Angelo Santoliquido, Carlo Filippo Porreca, Silvia Giovannini, Andrea Flex, Federico Biscetti, Giuseppe Straface, Luca Santoro, Giovanni Pecorini, Flavia Angelini, and Giovanni Ghirlanda
- Subjects
Male ,Genetic profile ,medicine.medical_specialty ,TNFRSF11B gene polymorphisms ,Biology ,Polymorphism, Single Nucleotide ,Gastroenterology ,Diabetes Complications ,Osteoprotegerin ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Genotype ,Genetics ,medicine ,Humans ,Stroke ,Genetic Association Studies ,Genetics (clinical) ,Aged ,Retrospective Studies ,Base Sequence ,Diabetes ,Settore MED/09 - MEDICINA INTERNA ,Case-control study ,Retrospective cohort study ,DNA ,medicine.disease ,Molecular medicine ,Italy ,History of ischemic stroke ,Case-Control Studies ,Female ,Restriction fragment length polymorphism - Abstract
Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. The present study aimed to evaluate whether OPG gene (TNFRSF11B) polymorphisms are involved in ischemic stroke in an Italian population with diabetes. Participants in a retrospective case–control study included 364 diabetic patients (180 males, 184 females) with history of ischemic stroke and 492 diabetic subjects without history of ischemic stroke (252 males, 240 females). The T245G, T950C, and G1181C polymorphisms of the OPG gene were analyzed by polymerase chain reaction and restriction fragment length polymorphism. We found that the T245G, T950C, and G1181C gene polymorphisms of the OPG gene were significantly (34.1 vs. 9.5 %, P
- Published
- 2012
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