1. DNA analysis in Turkish Duchenne/Becker muscular dystrophy families
- Author
-
Feza Deymeer, Ashhan Tolun, Esra Battaloglu, Coşkun Özdemir, Milhan Telatar, Faik Kuseyri, Memnune Yüksel Apak, and Piraye Serdaroglu
- Subjects
Male ,medicine.medical_specialty ,Turkey ,Duchenne muscular dystrophy ,DNA Mutational Analysis ,Biology ,Muscular Dystrophies ,law.invention ,law ,Complementary DNA ,Molecular genetics ,Multiplex polymerase chain reaction ,Genetics ,medicine ,Humans ,Muscular dystrophy ,Genetics (clinical) ,Polymerase chain reaction ,Southern blot ,medicine.disease ,Molecular biology ,Phenotype ,Chromosome Deletion ,Restriction fragment length polymorphism ,Polymorphism, Restriction Fragment Length - Abstract
The molecular genetics of Duchenne/Becker muscular dystrophy was investigated in 81 affected Turkish families. Deletions were detected by multiplex polymerase chain reaction assays and cDNA Southern analyses. The distribution of the deletions along the gene and their correlation to clinical phenotype were different from the studies reported on other populations. Moreover, DNA polymorphisms in mothers were determined using 8 DNA probes and three CA repeat sequences, and a high degree of informativeness was observed.
- Published
- 1992
- Full Text
- View/download PDF