1. A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease
- Author
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Jae-Jung, Kim, Young Mi, Hong, Saejung, Sohn, Gi Young, Jang, Kee-Soo, Ha, Sin Weon, Yun, Myung Ki, Han, Kyung-Yil, Lee, Min Seob, Song, Hyoung Doo, Lee, Dong Soo, Kim, Jong-Eun, Lee, Eun-Soon, Shin, Ji-Hyun, Jang, Yeon-Su, Lee, Sook-Young, Kim, Jong-Young, Lee, Bok-Ghee, Han, Jer-Yuarn, Wu, Kwi-Joo, Kim, Young-Mi, Park, Eul-Joo, Seo, In-Sook, Park, Jong-Keuk, Lee, and Jae-Moo, Lee
- Subjects
Adult ,Male ,Linkage disequilibrium ,Mucocutaneous zone ,Locus (genetics) ,Genome-wide association study ,Mucocutaneous Lymph Node Syndrome ,Biology ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Asian People ,Gene mapping ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetics (clinical) ,Coronary Aneurysm ,Odds ratio ,medicine.disease ,Chromosomes, Human, Pair 1 ,Genetic Loci ,Chromosomes, Human, Pair 2 ,Immunology ,Female ,Kawasaki disease ,Genome-Wide Association Study ,SNP array - Abstract
Kawasaki disease (KD) is an acute self-limited vasculitis of infants and children that manifests as fever and signs of mucocutaneous inflammation. Coronary artery aneurysms develop in approximately 15-25% of untreated children. Although the etiology of KD is largely unknown, epidemiologic data suggest the importance of genetic factors in the susceptibility to KD. In order to identify genetic variants that influence KD susceptibility, we performed a genome-wide association study (GWAS) using Affymetrix SNP array 6.0 in 186 Korean KD patients and 600 healthy controls; 18 and 26 genomic regions with one or more sequence variants were associated with KD and KD with coronary artery lesions (CALs), respectively (p
- Published
- 2011
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