1. Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma
- Author
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Bailey, Jessica N Cooke, Yaspan, Brian L, Pasquale, Louis R, Hauser, Michael A, Kang, Jae H, Loomis, Stephanie J, Brilliant, Murray, Budenz, Donald L, Christen, William G, Fingert, John, Gaasterland, Douglas, Gaasterland, Terry, Kraft, Peter, Lee, Richard K, Lichter, Paul R, Liu, Yutao, McCarty, Catherine A, Moroi, Sayoko E, Richards, Julia E, Realini, Tony, Schuman, Joel S, Scott, William K, Singh, Kuldev, Sit, Arthur J, Vollrath, Douglas, Wollstein, Gadi, Zack, Donald J, Zhang, Kang, Pericak-Vance, Margaret A, Allingham, R Rand, Weinreb, Robert N, Haines, Jonathan L, and Wiggs, Janey L
- Subjects
Aging ,Clinical Research ,Neurosciences ,Eye Disease and Disorders of Vision ,Human Genome ,Neurodegenerative ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Eye ,Acetyl Coenzyme A ,Case-Control Studies ,Cluster Analysis ,Female ,Genetic Predisposition to Disease ,Glaucoma ,Glaucoma ,Open-Angle ,Humans ,Intraocular Pressure ,Male ,Metabolic Networks and Pathways ,Models ,Genetic ,Polymorphism ,Single Nucleotide ,gamma-Aminobutyric Acid ,Complementary and Alternative Medicine ,Paediatrics and Reproductive Medicine ,Genetics & Heredity - Abstract
Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. Using genome-wide association single-nucleotide polymorphism data from the Glaucoma Genes and Environment study and National Eye Institute Glaucoma Human Genetics Collaboration comprising 3,108 cases and 3,430 controls, we assessed biologic pathways as annotated in the KEGG database for association with risk of POAG. After correction for genic overlap among pathways, we found 4 pathways, butanoate metabolism (hsa00650), hematopoietic cell lineage (hsa04640), lysine degradation (hsa00310) and basal transcription factors (hsa03022) related to POAG with permuted p
- Published
- 2014