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Your search keyword '"Jacob M. Keaton"' showing total 2 results
Start Over Author "Jacob M. Keaton" Journal human genomics
2 results on '"Jacob M. Keaton"'

1. Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans

Author

Meijian Guan, Jacob M. Keaton, Latchezar Dimitrov, Pamela J. Hicks, Jianzhao Xu, Nicholette D. Palmer, Lijun Ma, Swapan K. Das, Yii-Der I. Chen, Josef Coresh, Myriam Fornage, Nora Franceschini, Holly Kramer, Carl D. Langefeld, Josyf C. Mychaleckyj, Rulan S. Parekh, Wendy S. Post, Laura J. Rasmussen-Torvik, Stephen S. Rich, Jerome I. Rotter, John R. Sedor, Denyse Thornley-Brown, Adrienne Tin, James G. Wilson, Barry I. Freedman, Donald W. Bowden, Maggie C. Y. Ng, and FIND Consortium

Subjects
African Americans, Genome-wide association study, Type 2 diabetes, Diabetic kidney disease, End-stage kidney disease, Medicine, Genetics, QH426-470
Abstract

Abstract Background End-stage kidney disease (ESKD) is a significant public health concern disproportionately affecting African Americans (AAs). Type 2 diabetes (T2D) is the leading cause of ESKD in the USA, and efforts to uncover genetic susceptibility to diabetic kidney disease (DKD) have had limited success. A prior genome-wide association study (GWAS) in AAs with T2D-ESKD was expanded with additional AA cases and controls and genotypes imputed to the higher density 1000 Genomes reference panel. The discovery analysis included 3432 T2D-ESKD cases and 6977 non-diabetic non-nephropathy controls (N = 10,409), followed by a discrimination analysis in 2756 T2D non-nephropathy controls to exclude T2D-associated variants. Results Six independent variants located in or near RND3/RBM43, SLITRK3, ENPP7, GNG7, and APOL1 achieved genome-wide significant association (P

Published
2019
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2. Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans

Author

Jianzhao Xu, Nora Franceschini, Pamela J. Hicks, Meijian Guan, Wendy S. Post, Swapan K Das, Lijun Ma, Barry I. Freedman, John R. Sedor, Yii-Der Ida Chen, Denyse Thornley-Brown, Laura J. Rasmussen-Torvik, Donald W. Bowden, Josef Coresh, Jacob M. Keaton, Carl D. Langefeld, Maggie C.Y. Ng, Adrienne Tin, Holly Kramer, Josyf C. Mychaleckyj, Jerome I. Rotter, Stephen S. Rich, Nicholette D. Palmer, Myriam Fornage, Latchezar Dimitrov, Rulan S. Parekh, and James G. Wilson

Subjects
Genome-wide association study, medicine.medical_specialty, lcsh:QH426-470, lcsh:Medicine, Locus (genetics), Type 2 diabetes, Disease, 03 medical and health sciences, Internal medicine, Drug Discovery, Genotype, Genetics, Genetic predisposition, Medicine, Diabetic kidney disease, 1000 Genomes Project, Molecular Biology, African Americans, 0303 health sciences, business.industry, lcsh:R, 030305 genetics & heredity, End-stage kidney disease, medicine.disease, 3. Good health, lcsh:Genetics, Molecular Medicine, Primary Research, business, Kidney disease
Abstract

Background End-stage kidney disease (ESKD) is a significant public health concern disproportionately affecting African Americans (AAs). Type 2 diabetes (T2D) is the leading cause of ESKD in the USA, and efforts to uncover genetic susceptibility to diabetic kidney disease (DKD) have had limited success. A prior genome-wide association study (GWAS) in AAs with T2D-ESKD was expanded with additional AA cases and controls and genotypes imputed to the higher density 1000 Genomes reference panel. The discovery analysis included 3432 T2D-ESKD cases and 6977 non-diabetic non-nephropathy controls (N = 10,409), followed by a discrimination analysis in 2756 T2D non-nephropathy controls to exclude T2D-associated variants. Results Six independent variants located in or near RND3/RBM43, SLITRK3, ENPP7, GNG7, and APOL1 achieved genome-wide significant association (P

Published
2019

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