1. Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDHIAI*4
- Author
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Lucinda G. Carr, Shelley Moore, Cindy L. Ehlers, Kevin McCall, Tamara Graves, and Tiebing Liang
- Subjects
lcsh:QH426-470 ,Genotype ,Base pair ,lcsh:Medicine ,Aldehyde dehydrogenase ,Polymerase Chain Reaction ,law.invention ,polymorphism ,Cytosol ,law ,Polymorphism (computer science) ,base pair ,Drug Discovery ,Genetics ,Humans ,Allele ,Molecular Biology ,Polymerase chain reaction ,Alleles ,DNA Primers ,biology ,Base Sequence ,lcsh:R ,Aldehyde Dehydrogenase ,Molecular biology ,Human genetics ,ALDHIAI ,lcsh:Genetics ,Trinidad and Tobago ,biology.protein ,Molecular Medicine ,Primary Research - Abstract
This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 (ALDHIAI) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDHIAI allele, ALDHIAI*4, was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.
- Published
- 2009