1. Associations of killer cell immunoglobulin-like receptors with acute myeloid leukemia in Chinese populations
- Author
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Faming Zhu, Sudan Tao, Jun-Jun He, Wei Wang, L.-N. Dong, Yanmin He, Z.-D. Han, N.-Y. Chen, Ji He, and Wei Zhang
- Subjects
0301 basic medicine ,China ,Genotype ,Immunology ,chemical and pharmacologic phenomena ,HLA-C Antigens ,Human leukocyte antigen ,Ligands ,Polymerase Chain Reaction ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Gene Frequency ,Receptors, KIR ,HLA Antigens ,hemic and lymphatic diseases ,Genetic variation ,otorhinolaryngologic diseases ,HLA-B Antigens ,Humans ,Protein Isoforms ,Immunology and Allergy ,Medicine ,Genetic Predisposition to Disease ,Receptor ,Allele frequency ,HLA-A Antigens ,biology ,business.industry ,Genetic Variation ,Myeloid leukemia ,hemic and immune systems ,Sequence Analysis, DNA ,General Medicine ,Leukemia, Myeloid, Acute ,030104 developmental biology ,biology.protein ,Antibody ,business ,030215 immunology - Abstract
Many studies have investigated the relationship between KIR, HLA and acute myeloid leukemia (AML), but the results were different in different laboratories, and the data in Chinese population were limited. In this study, the distribution of KIR gene, KIR genotypes, HLA-C groups, HLA-Bw4, and KIR-HLA interaction from 273 healthy participants and 253 AML patients (M0-M6) in southern Chinese Han were determined to investigate the relationships among KIR, HLA and AML. The results showed that the frequencies of 2DS4del in M5 patients were significantly higher than those of the controls (65.0% vs 46.5%, P=0.0104, OR=2.135, P
- Published
- 2017