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Start Over Author "N Y Chen" Journal human immunology
2 results on '"N Y Chen"'

1. Associations of killer cell immunoglobulin-like receptors with acute myeloid leukemia in Chinese populations

Author

Faming Zhu, Sudan Tao, Jun-Jun He, Wei Wang, L.-N. Dong, Yanmin He, Z.-D. Han, N.-Y. Chen, Ji He, and Wei Zhang

Subjects
0301 basic medicine, China, Genotype, Immunology, chemical and pharmacologic phenomena, HLA-C Antigens, Human leukocyte antigen, Ligands, Polymerase Chain Reaction, 03 medical and health sciences, 0302 clinical medicine, Asian People, Gene Frequency, Receptors, KIR, HLA Antigens, hemic and lymphatic diseases, Genetic variation, otorhinolaryngologic diseases, HLA-B Antigens, Humans, Protein Isoforms, Immunology and Allergy, Medicine, Genetic Predisposition to Disease, Receptor, Allele frequency, HLA-A Antigens, biology, business.industry, Genetic Variation, Myeloid leukemia, hemic and immune systems, Sequence Analysis, DNA, General Medicine, Leukemia, Myeloid, Acute, 030104 developmental biology, biology.protein, Antibody, business, 030215 immunology
Abstract

Many studies have investigated the relationship between KIR, HLA and acute myeloid leukemia (AML), but the results were different in different laboratories, and the data in Chinese population were limited. In this study, the distribution of KIR gene, KIR genotypes, HLA-C groups, HLA-Bw4, and KIR-HLA interaction from 273 healthy participants and 253 AML patients (M0-M6) in southern Chinese Han were determined to investigate the relationships among KIR, HLA and AML. The results showed that the frequencies of 2DS4del in M5 patients were significantly higher than those of the controls (65.0% vs 46.5%, P=0.0104, OR=2.135, P

Published
2017

2. Comparison of the KIR3DS1/Bw4 distribution in Chinese healthy and acute myeloid leukemia individuals

Author

Wei Zhang, Ji He, Sudan Tao, Wei Wang, Faming Zhu, Hangjun Lv, L.-N. Dong, Yanmin He, Z.-D. Han, Jun-Jun He, and N.-Y. Chen

Subjects
China, Receptors, KIR3DS1, Genotype, DNA Mutational Analysis, Immunology, Killer-cell immunoglobulin-like receptor, Disease, Human leukocyte antigen, Gene Frequency, hemic and lymphatic diseases, HLA-B Antigens, Humans, Immunology and Allergy, Medicine, Genetic Predisposition to Disease, Allele frequency, Genetic Association Studies, Aged, Polymorphism, Genetic, business.industry, Myeloid leukemia, General Medicine, HLA-B, Killer Cells, Natural, Leukemia, Myeloid, Acute, business, Protein Binding
Abstract

Killer cell immunoglobulin like receptor (KIR) 3DS1 is one of the most important activating receptors and some studies revealed that KIR3DS1 combined with HLA ligand was not related to acute myeloid leukemia (AML), but rare data was reported in Chinese population. In this study, KIR3DS1 gene polymorphisms and HLA-Bw4 were investigated in 189 Chinese AML patients compared with 166 healthy individuals. The results showed that the distributions of KIR3DS1, Bw4, 3DS1/Bw4 and 3DS1/Bw4-80I were insignificantly different between AML and healthy individuals. This study suggests that the presence of 3DS1 and HLA-Bw4 ligands have no effect on AML disease.

Published
2015

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