1. Mallory bodies in scar adenocarcinoma of the lung
- Author
-
James J. Limacher, René P. Michel, and R. John Kimoff
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Alcoholic liver disease ,Hyalin ,Lung Neoplasms ,Autopsy ,Biology ,Adenocarcinoma ,Pathology and Forensic Medicine ,Metastatic carcinoma ,Immunoenzyme Techniques ,Cicatrix ,Adenocarcinoma of the lung ,medicine ,Mallory body ,Humans ,Lung cancer ,Aged ,Inclusion Bodies ,Staining and Labeling ,Brain Neoplasms ,medicine.disease ,Microscopy, Electron ,Hepatocellular carcinoma ,biology.protein ,Antibody - Abstract
A 75 year old man presented with metastatic carcinoma to the brain. At autopsy a primary scar adenocarcinoma of the lung was found. By light microscopy the cytoplasm of the tumor cells was seen to contain hyalin masses with tinctorial properties identical to those of the Mallory bodies seen in human alcoholic liver disease and in hepatocellular carcinoma. The hyalin stained positively with anti-Mallory body antibody by the peroxidase antiperoxidase technique, and had the characteristic filamentous and granular amouphous appearance of alcoholic hyalin by electron microscopy. Our observation is of interest in light of recent information relating Mallory bodies to prekeratin, and vitamin A deficiency to lung cancer.
- Published
- 1982