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Start Over Author "Gu WP" Journal hunan yi ke da xue xue bao hunan yike daxue xuebao bulletin of hunan medical university
2 results on '"Gu WP"'

1. [Study on p53 gene expression following transient ischemia in the gerbil].

Author

Gu WP, Yang QD, and Xie GJ

Subjects
Animals, Apoptosis, Genes, p53, Gerbillinae, Ischemic Attack, Transient metabolism, Male, RNA, Messenger biosynthesis, RNA, Messenger genetics, Random Allocation, Rats, Reperfusion Injury metabolism, Tumor Suppressor Protein p53 genetics, Ischemic Attack, Transient genetics, Reperfusion Injury genetics, Tumor Suppressor Protein p53 biosynthesis
Abstract

Objective: To study the expression of p53 gene after transient ischemia in the gerbil., Methods: Northern blot was used to detect the expression of the p53 mRNA in the forebrain during different periods after post-ischemic reperfusion in the gerbil., Results: The expression of p53 mRNA increased in the forebrain during the 6th hour to the 3rd day of reperfusion following 6 min of ischemia (P < 0.05)., Conclusion: The high level expression of p53 might induce neuronal apoptosis after ischemia.

Published
2001

2. [Heat shock protein 70 expression following transient ischemia in the gerbil].

Author

Gu WP, Yang QD, and Xie GJ

Subjects
Animals, Brain pathology, Gerbillinae, Male, Neurons pathology, Rats, HSP70 Heat-Shock Proteins biosynthesis, Heat-Shock Response physiology, Ischemic Attack, Transient metabolism
Abstract

Objective: To study the expression of heat shock protein 70(HSP70) following transient ischemia in the gerbil., Methods: Immunohistochemistry(IHC) was used to determine the expression of the HSP70 protein in the forebrain during different periods after post-ischemic reperfusion in the gerbil, and the neuronal damage was examined with microscope., Results: The HSP70 protein was only expressed at the 1st day of reperfusion(P < 0.01); and most of the neurons showed damage on the 7th day of reperfusion; heat-preconditioning could increase the expression of HSP70 protein(P < 0.01) and decrease the neuronal damage(P < 0.001) after 6 min of ischemia., Conclusion: Heat-preconditioning could protect neural cells from damage by increasing the expression of the HSP70 protein.

Published
2000

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