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Increased prevalence of insulin resistance in patients with nonalcoholic fatty liver disease (NAFLD) has been demonstrated in various studies. However, there are only few references regarding the relationship between plasma insulin values or insulin sensitivity index and the biochemical severity of liver infiltration. The aim of this study was to examine a relationship between symptoms of the metabolic syndrome, i.e. insulin resistance, body weight and plasma lipoproteins and the laboratory parameters of liver fatty infiltration in patients with nonalcoholic fatty liver disease. There was found a significant positive correlation between plasma insulin and alaninaminotransferase ( r = 0.359, p < 0.01) and a significant positive correlation between plasma insulin and aspartateaminotransferase ( r = 0.42, p < 0.01). Additionally, a significant positive correlation was found between the index of insulin resistance (HOMA index) and alaninaminotransferase ( r = 0.637, p < 0.01) and a significant positive correl...

Non-alcoholic fatty liver disease (NAFLD) is an acquired metabolic disease of the liver caused by accumulation of triglycerides in the hepatocytes followed by necrobiotic inflammatory reaction, fibrosis, and even cirrhosis. The accumulation of fatty acids in consequence of insulin resistance lies in the background of the process; the next step of pathogenesis is activation of microsomal polysubstrate systems and the oxidative stress caused by the released free radicals. Obesity, insulin resistance, diabetes mellitus and hyperlipidaemia are important pathogenetic factors. Patients with cholelithiasis and with a history of diabetes mellitus are known to have complications of cholelithiasis more frequently in comparison to those without diabetes. Objective: The aim of the study was the observation of the incidence of cholelithiasis and its complications in patients with NAFLD, as well as the comparison of the incidence of cholelithiasis between healthy persons and patients with NAFLD. Method: Abdominal ultra...