This review paper focuses on the question of what will happen to the future water resource system of Grand Renaissance Dam of Ethiopia based on the projected hydrology of the Upper Blue Nile River basin. For this, the hydrological extremes, the baseline hydrological trends, and projected hydrological extremes of the Upper Blue Nile River basin were reviewed from various published and unpublished sources. Changes in the future hydrology of the Upper Blue Nile River basin due to climate change or any other natural or manmade modification of the river basin deserve concerted attention in the future water resources system of the Grand Renaissance Dam of Ethiopia, because the water resources of the dam mainly depend on the water potential nature of the Upper Blue Nile River basin. [ABSTRACT FROM AUTHOR]