1. Diurnal Variation in Blood Pressure and Arterial Stiffness in Chronic Kidney Disease
- Author
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Vanessa Melville, Robert Kimmitt, David J. Webb, Iain M. MacIntyre, Ewan D. Kennedy, Wilna Oosthuyzen, Kayleigh E. Brown, Jane Goddard, Neeraj Dhaun, and Rebecca Moorhouse
- Subjects
Adult ,Endothelin Receptor Antagonists ,Male ,medicine.hormone ,medicine.medical_specialty ,Blood Pressure ,Thiophenes ,Essential hypertension ,Endothelins ,Vascular Stiffness ,Internal medicine ,Sitaxentan ,Internal Medicine ,Humans ,Medicine ,Renal Insufficiency, Chronic ,Pulse wave velocity ,Endothelin-1 ,business.industry ,Isoxazoles ,Middle Aged ,medicine.disease ,Circadian Rhythm ,Pulse pressure ,Blood pressure ,Endocrinology ,Case-Control Studies ,Arterial stiffness ,Cardiology ,Female ,business ,Kidney disease ,medicine.drug - Abstract
Abstract— Hypertension and arterial stiffness are important independent cardiovascular risk factors in chronic kidney disease (CKD) to which endothelin-1 (ET-1) contributes. Loss of nocturnal blood pressure (BP) dipping is associated with CKD progression, but there are no data on 24-hour arterial stiffness variation. We examined the 24-hour variation of BP, arterial stiffness, and the ET system in healthy volunteers and patients with CKD and the effects on these of ET receptor type A receptor antagonism (sitaxentan). There were nocturnal dips in systolic BP and diastolic BP and pulse wave velocity, our measure of arterial stiffness, in 15 controls (systolic BP, −3.2±4.8%, P P =0.001; pulse wave velocity, −5.8±5.2%, P P P P Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifiers: NCT01770847 and NCT00810732.
- Published
- 2014