1. Downregulation of
- Author
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František, Liška, Vladimír, Landa, Václav, Zídek, Petr, Mlejnek, Jan, Šilhavý, Miroslava, Šimáková, Hynek, Strnad, Jaroslava, Trnovská, Vojtěch, Škop, Ludmila, Kazdová, Colby G, Starker, Daniel F, Voytas, Zsuzsanna, Izsvák, Massimiliano, Mancini, Ondřej, Šeda, Vladimír, Křen, and Michal, Pravenec
- Subjects
Male ,Analysis of Variance ,Gene Expression Profiling ,Blotting, Western ,Quantitative Trait Loci ,Kruppel-Like Transcription Factors ,Down-Regulation ,Blood Pressure Determination ,Lipid Metabolism ,Real-Time Polymerase Chain Reaction ,Fibrosis ,Rats ,Phenotype ,Rats, Inbred SHR ,Hypertension ,Animals ,Hypertrophy, Left Ventricular ,Myocytes, Cardiac ,Promyelocytic Leukemia Zinc Finger Protein ,Essential Hypertension ,Alleles ,Cells, Cultured - Abstract
The spontaneously hypertensive rat (SHR), one of the most widely used model of essential hypertension, is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, quantitative trait loci influencing blood pressure, left ventricular mass, and heart interstitial fibrosis were genetically isolated within a minimal congenic subline that contains only 7 genes, including mutant
- Published
- 2016