1. Diurnal Blood Pressure Abnormalities Are Related to Endothelial Dysfunction in Patients with Non-Complicated Type 1 Diabetes
- Author
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Ahmet Toprak, Hakan Tezcan, Oguzhan Deyneli, Hasan Aydin, Meral Yüksel, Sema Akalin, Dilek Gogas Yavuz, Dilek Yazici, Deyneli, Oguzhan, Yazici, Dilek, Toprak, Ahmet, Yuksel, Meral, Aydin, Hasan, Tezcan, Hakan, Yavuz, Dilek Gogas, and Akalin, Sema
- Subjects
Adult ,Male ,medicine.medical_specialty ,Ambulatory blood pressure ,AUTONOMIC NEUROPATHY ,Endothelium ,Physiology ,Blood Pressure ,Nitric Oxide ,Thiobarbituric Acid Reactive Substances ,DISEASE ,MELLITUS ,endothelial function ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,TBARS ,Humans ,oxidative stress ,ESSENTIAL-HYPERTENSION ,Endothelial dysfunction ,nondipper ,IDDM PATIENTS ,Glycated Hemoglobin ,Type 1 diabetes ,diabetes ,biology ,Dipper ,business.industry ,MORTALITY ,Cholesterol, LDL ,medicine.disease ,biology.organism_classification ,Circadian Rhythm ,Vasodilation ,ambulatory blood pressure monitoring ,Diabetes Mellitus, Type 1 ,Endocrinology ,Blood pressure ,medicine.anatomical_structure ,6-YEAR FOLLOW-UP ,DEPENDENT VASODILATION ,Cardiology ,Female ,Endothelium, Vascular ,BLUNTED NOCTURNAL FALL ,Cardiology and Cardiovascular Medicine ,business - Abstract
Patients with diabetes have an increased cardiovascular morbidity and mortality despite interventions to prevent these outcomes. Abnormalities in diurnal blood pressure patterns are also associated with excess cardiovascular mortality. The aim of this study was to determine the effects of diurnal blood pressure patterns on endothelial function and oxidative stress in patients with uncomplicated type 1 diabetes mellitus. Thirty-two normotensive and normoalbuminuric type 1 diabetic patients (21 dipper and 11 nondipper) and 37 healthy (27 dipper and 10 nondipper) volunteers underwent 24-h ambulatory blood pressure monitoring. Their endothelial functions were evaluated using flow mediated dilatation (FMD) and by measuring nitric oxide and thiobarbituric acid reactive substances (TBARS). Dippers were defined as subjects who exhibited an average reduction in both systolic and diastolic blood pressure of greater than 10% between day and night periods. Nondipper type 1 diabetic patients and controls had nighttime systolic and diastolic blood pressure values that were significantly higher than those of dipper diabetic patients (p
- Published
- 2008
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