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Hemodynamics in stenosed arteries is complex, including turbulence, recirculation, and vortices, which can further worsen the disease. This study provides an overview of blood flow characteristics in stenosed arteries, focusing on flow physics, stenosis geometry, and severity. This present article examines the impact of heat and mass exchange on blood flow in arterial stenosis, taking into account chemical processes, magnetic fields, and thermal radiation. The features of vital fluid (blood) in the constricted arterial tube are examined by taking blood as Newtonian fluid in the arterial stenosis region. The continuity (mass), momentum, and concentration equations are solved using a finite difference approach with the help of appropriate boundary conditions. Solutions have been established for axial velocity, temperature, and concentration equations with variable parameters in blood circulation. It is noticed that an enhancement in the Reynolds number indicates more disorder in the velocity of the blood flow near the downstream area of cholesterol or plaque deposition. The temperature profile induced is stronger nearer to the arterial complaint wall downstream of stenosis. These findings for RBC's flow in stenosis-contained arteries have significant advantages in terms of understanding the disease mechanisms, developing accurate computational models, and identifying effective treatment strategies for patients. [ABSTRACT FROM AUTHOR]