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Creating an effective and efficient distribution plan is a considerable challenge owing to urgency, incomplete information, and surging demands. In this study, a planning method based on a sliding time window series is designed to solve the problem of drug distribution in earthquake responses. First, this study presents a method designed to generate a series of sliding time windows considering time-varying demands. Second, a method is proposed to determine the effectiveness of the drug distribution plan according to its evaluation standards. Third, a dynamic planning model is established considering the sliding time window series and group information updates. Fourth, a simulation study is conducted to test the models and algorithms. Simulation results show that specific drug distribution plans should be provided to emergency planners in the event of an earthquake. The sliding time window series and group information updates are key factors in creating an effective drug distribution plan as part of an earthquake response.