1. Robust predictive control strategy applied for propofol dosing using BIS as a controlled variable during anesthesia.
- Author
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Ionescu CM, De Keyser R, Torrico BC, De Smet T, Struys MM, and Normey-Rico JE
- Subjects
- Anesthetics, Intravenous administration & dosage, Computer Simulation, Dose-Response Relationship, Drug, Drug Administration Schedule, Feedback drug effects, Feedback physiology, Humans, Algorithms, Anesthesia methods, Anesthetics administration & dosage, Drug Therapy, Computer-Assisted methods, Electroencephalography drug effects, Models, Biological, Propofol administration & dosage
- Abstract
This paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. The performance of a generic predictive control strategy in drug dosing control, with a previously reported anesthesia-specific control algorithm, has been evaluated. The robustness properties of the predictive controller are evaluated with respect to inter- and intrapatient variability. A single-input (propofol) single-output (bispectral index, BIS) model of the patient has been assumed for prediction as well as for simulation. A set of 12 patient models were studied and interpatient variability and disturbances are used to assess robustness of the controller. Furthermore, the controller guarantees the stability in a desired range. The applicability of the predictive controller in a real-life environment via simulation studies has been assessed.
- Published
- 2008
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