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Objective: This paper presents a Proof-of-Concept (POC) design and implementation of a biosensing and communication system that can be used for biotelemetry in neural and Gastrointestinal (GI) applications. Methods: Our proposed system is based on backscattering from a semi-passive Radio-Frequency-Identification-Device (RFID) implemented using an Application Specific Integrated Circuit (ASIC) in which electronic switching between transistor gates in high and low states create an impedance difference, thereby effectively changing the ASIC's Radar Cross Section (RCS) and thus modulating its backscattered field. The ASIC is used in conjunction with a biosensor to measure and transmit vital signs from within the body. With this system, we conducted backscatter propagation experiments through different biological and phantom tissues (in ex-vivo and in-vitro) in the GI and neural environments. Results: Our results show that the backscattered waveforms can penetrate tissues of various compositions and thicknesses with power received at distances of up to 55 cm away from the RFID ASIC. Furthermore, results from single- and multi-bit biotelemetry measurements showed a high signal fidelity with low Bit-Error-Rate (BER) while being able to resolve varying tissue temperatures measured by the biosensor in our system. Conclusion: We realized a POC system in which on-chip transistor switching in an ASIC can be used to achieve backscatter communication and biosensing. This system is deployable in neural and GI applications. Significance: Our findings in this work will provide an important practical basis for the design and development of RFID ASIC for biosensing and biotelemetry in medical applications. [ABSTRACT FROM AUTHOR]