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1. A Surface-Based Approach to Quantify Local Cortical Gyrification.

Author

Schaer, Marie, Cuadra, Meritxell Bach, Tamarit, Lucas, Lazeyras, Francois, Eliez, Stephan, and Thiran, Jean-Philippe

Subjects
CEREBRAL cortex, MEDICAL imaging systems, DIAGNOSTIC imaging, BIOLOGY, MEDICINE
Abstract

The high complexity of cortical convolutions in humans is very challenging both for engineers to measure and compare it, and for biologists and physicians to understand it. In this paper, we propose a surface-based method for the quantification of cortical gyrification. Our method uses accurate 3-D cortical reconstruction and computes local measurements of gyrification at thousands of points over the whole cortical surface. The potential of our method to identify and localize precisely gyral abnormalities is illustrated by a clinical study on a group of children affected by 22q11 Deletion Syndrome, compared to control individuals. [ABSTRACT FROM AUTHOR]

Published
2008
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2. Novel Surface-Smoothing Based Local Gyrification Index

Author

Mirza Faisal Beg, Lei Wang, Evgeniy Lebed, and Claudia Jacova

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Databases, Factual, Biology, Temporal lobe, Atrophy, Gyrus, Alzheimer Disease, Image Processing, Computer-Assisted, medicine, Humans, Dementia, Computer Simulation, Cortical surface, Electrical and Electronic Engineering, Gyrification, Aged, Aged, 80 and over, Analysis of Variance, Radiological and Ultrasound Technology, Brain, Reproducibility of Results, Middle Aged, Neurophysiology, medicine.disease, Magnetic Resonance Imaging, Computer Science Applications, medicine.anatomical_structure, Case-Control Studies, Female, Alzheimer's disease, Neuroscience, Algorithms, Software
Abstract

The quantication of cortical surface folding is important in identifying and classifying many neurodegenerative diseases. Much work has been done to identify regional and global brain folding, and in this paper we review some of these methods, as well as propose a new method that has advantages over the existing state of art. Using our novel proposed method, we mapped the local gyrification index on the cortical surface for subjects with mild Alzheimer's dementia (n=20) , very mild dementia (n=23) and age-matched healthy subjects (n=52). In our experiments we find a consistent pattern of gyrification changes in the dementia subjects, with regions generally affected early on in the progression of Alzheimer pathology, including medial temporal lobe, and cingulate gyrus, having decreased gyrification. At the same time we observe increased gyrification in dementia subjects, in frontal, anterior temporal and posteriorly located regions. We speculate that in neurodegenerative diseases including Alzheimer Disease, the folding of the entire cortical mantle undergoes dynamic changes as regional atrophy begins and expands, with both decreases and increases in gyrification.

Published
2013